Our Mission: We are a computational biology and genomics laboratory in the Department of Genetics at the University of Alabama at Birmingham. We conduct cutting-edge research focused on understanding the genetic and epigenetic mechanisms contributing to tumor cell heterogeneity, differentiation status, and therapeutic resistance in pediatric cancers.
Our Vision: Our vision is to use a combination of molecular biology, CRISPR-based genetic perturbations screens and Next Generation Sequencing (NGS) approaches to streamline discovery of driver mutations and interpret how they contribute to tumorigenesis. As a part of the Precision Medicine Institute, we are also designing and implementing machine-learning approaches that can predict the impact of non-coding mutations on epigenetic and gene expression patterns.
