CARDIA Activity and Heart Failure Study
The Coronary Artery Risk Development in Young Adults (CARDIA) study was established in 1985-86 to examine the development and determinants of clinical and subclinical cardiovascular disease and their risk factors. At baseline, the cohort included 5,115 Black and White men and women between the ages of 18-30 years enrolled at one of four U.S. clinical centers including: Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA. The CARDIA Coordinating Center is located in Birmingham, AL. Please visit the CARDIA website for more information (https://www.cardia.dopm.uab.edu/).
The CARDIA Activity and Heart Failure (ACT-HF) Study is an ancillary study to the CARDIA Year 35 follow-up exam. The overall study goal is to examine the associations of changes in cardiorespiratory fitness and reported physical activity from young adulthood to midlife, and changes in accelerometer-based measures of physical activity and sedentary time during midlife, with heart failure risk and state progression, or improvement. Measures Added: 1) activity monitor (ActiGraph; also at Year 20 and 30 follow-up exams), 2) maximal graded exercise test with gas analysis (also at baseline and Year 7 and 20 follow-up exams), and heart failure biomarkers, including N-terminal-proBNP and high sensitivity cardiac troponin T (Year 20, 30, and 35 follow-up exams).
Current Study Stage. Data collection completed; data processing and analysis ongoing.
Funding Source. The CARDIA ACT-HF study is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award number R01HL149796 to K. Gabriel.
JACKSON 24-H Activity Cycles Study
The Jackson Heart Study (JHS) was established in 1998 to examine the genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease in African Americans. JHS also conducts community education and outreach activities. The JHS represents an expansion of the Jackson, MS clinical center for the Atherosclerosis Risk in Communities (ARIC) study. At baseline, JHS included 5,306 Black men and women between the ages of 35-84 years residing in the Jackson, MS metropolitan area. Please visit the JHS website for more information (https://www.jacksonheartstudy.org/).
The Jackson 24H Activity Cycles Study (Jackson 24H-ACT) is an ancillary study to the JHS Exam 4. The overall study goal is to quantify 24-hour cycle behaviors and examine the independent and joint roles of waking (sedentary to vigorous intensity physical activity) and sleep (duration and quality) estimates on brain health outcomes, including cognitive functioning, subclinical markers of cerebrovascular disease, white matter microstructural integrity, and neurodegeneration. Measures Added: 1) activity monitor (ActiGraph) and 2) sleep actigraphy (GENEActiv).
Current Study Stage. Participant enrollment, data collection, and data processing ongoing.
Funding Source. The Jackson 24H-ACT Study is supported by the National Institute on Aging of the National Institutes of Health under award number R01AG077513 to K. Gabriel and P. Palta [University of North Carolina at Chapel Hill].
MESA 24-H Activity Cycles Study
The Multi-Ethnic Study of Atherosclerosis (MESA) was established in 2000 to examine the characteristics of subclinical cardiovascular disease and the risk factors that predict progression to clinically overt disease or progression of subclinical disease. At baseline, the cohort included 6,814 men and women aged 45-84 from six U.S. clinical centers including: Wake Forest University, Columbia University, Johns Hopkins University, University of Minnesota, Northwestern University, and the University of California at Los Angeles. Please visit the MESA website for more information (https://www.mesa-nhlbi.org/).
The MESA 24H Activity Cycles Study (MESA 24H-ACT) is an ancillary study to the MESA Exam 7. The overall study goal is to quantify 24-hour cycle behaviors and examine the 1) cross-sectional associations of 24 hour activity cycle behaviors with cognition, markers of cerebrovascular disease, neurodegeneration, amyloid burden, and prevalence of mild cognitive impairment and dementia, 2) prospective associations of self-reported 24-hour cycle behaviors and global cognitive function, cerebrovascular disease, and neurodegeneration, and 3) bidirectional association between impaired cognitive function and 24-hour activity cycles over 12 years. Measures Added: 1) activity monitor (ActiGraph) and 2) sleep actigraphy (GENEActiv; in collaboration with R01AG070867 [S. Redline and S. Purcell; Brigham and Women’s Hospital]).
Current Study Stage. Participant enrollment, data collection, and data processing ongoing.
Funding Source. The MESA 24H-ACT Study is supported by the National Institute on Aging of the National Institutes of Health under award number R01AG071032 to P. Palta [University of North Carolina at Chapel Hill], K. Diaz [Columbia University], and K. Gabriel.
REGARDS 24-H Activity Cycles Study
The REasons for Geographic and Racial Differences in Stroke (REGARDS) study is designed to understand why people in some parts of the country develop more strokes than people in other parts of the country, and why Black Americans develop more strokes than White Americans. The overall goal of REGARDS is to reduce the number of people having strokes. Between 2003 to 2007, 30,239 participants aged 45 years or older were recruited across the U.S. They completed a telephone interview followed by an in-home physical exam. Measurements included traditional risk factors such as blood pressure and cholesterol levels and an electrocardiogram of the heart. At six month intervals, participants are contacted by phone to ask about stroke symptoms, hospitalizations, and general health status. Please visit the REGARDS website for more information (https://www.uab.edu/soph/regardsstudy/).
The REGARDS 24H Activity Cycles Study (REGARDS 24H-ACT) is an ancillary study to REGARDS. The overall study goal is to quantify 24-hour cycle behaviors to characterize the temporal, bidirectional relationship between the 24-h activity cycle and adverse cognitive outcomes. Specifically, we will test whether: 1) composition of the 24-h activity cycle predicts change in cognitive function and incident mild cognitive impairment (MCI) or dementia, 2) cognitive function and prevalent MCI/dementia predict change in composition of the 24-h activity cycle, and 3) change in the composition of the 24-h activity cycle is associated with change in cognitive function and transitions in cognitive impairment status. Measures Added: 1) activity monitor (ActiGraph) and 2) sleep actigraphy (GENEActiv).
Current Study Stage. Participant enrollment, data collection, and data processing ongoing.
Funding Source. The REGARDS 24H-ACT Study is supported by the National Institute on Aging of the National Institutes of Health under award number RF1AG077707 to K. Diaz [Columbia University], K. Gabriel, and P. Palta [University of North Carolina at Chapel Hill].
Dallas Heart 24-REACT Study
The Dallas Heart Study (DHS) was initiated in 2000 with the overall goal of improving the diagnosis, prevention, and treatment of heart disease. Between 2000 to 2002, 6,000 residents of Dallas County, aged 18-65 years, completed a detailed medical survey. They completed a telephone interview followed by an in-home physical exam. Measurements include blood samples and comprehensive state-of-the-art imaging studies to assess plaque buildup in the blood vessels of the heart, the size and function of the heart, and the amount and distribution of body fat. Starting in 2021, the Dallas Hearts and Minds Study (DHMS), a continuation of the DHS, added an activity monitor (ActiGraph Link). Please visit the DHS website for more information (https://www.utsouthwestern.edu/education/medical-school/departments/internal-medicine/research/dallas-heart/).
The Dallas Heart 24-Hour Rest-Activity Cycle Study (DHS 24-REACT) is a Career Development Award funded by the American Heart Association to E. Dooley. The overall study goal is to 1) apply a novel statistical method for time-use data to construct enhanced 24-h rest-activity phenotypes that consider accumulation patterns and 2) examine associations of 24-h rest-activity phenotypes with multimorbidity.
Funding Source. The DHS 24-REACT Study is supported by the American Heart Association Grant # 23CDA1049277 to E. Dooley.
Study of Women’s Health Across the Nation (SWAN)
The Study of Women’s Health Across the Nation was established in 1994 with the overall goal of examining the physical, biological, psychological, and social changes during the menopausal transition. Between 1996 to 1997, 3,302 participants were enrolled at one of seven research centers, including: University of Michigan, Massachusetts General Hospital, Rush University Medical Center, University of California Davis and Kaiser Permanente, University of California at Lost Angeles, Albert Einstein College of Medicine, and University of Pittsburgh. SWAN participants represent five racial / ethnic groups. To date, SWAN participants have completed the screening, baseline, and 16 follow-up visits, which take place approximately every year. Please visit the SWAN website for more information (https://www.swanstudy.org/).
Self-reported physical activity has been regularly ascertained since the baseline exam. First measures of accelerometry were collected at Visit 15 (with sleep actigraphy). These measures are being re-collected as part of the ongoing Visit 17 exam. Efforts are currently underway to harmonize sleep-waking data to examine associations of 24-hour activity cycle with several health outcomes.
Citation. Dooley EE (ǂ), Winkles JF, Colvin A, Kline CE, Badon SE, Diaz KM, Karvonen-Gutierrez CA, Kravitz HM, Sternfeld B, Thomas SJ, Hall MH, Pettee Gabriel K. 2023. Method for activity sleep harmonization (MASH): Harmonizing data from two wearable devices to estimate 24-hr movement cycles. Journal of Activity, Sedentary and Sleep Behaviors. 2: 8. ǂDooley and Winkles share first authorship
Funding Source. The SWAN Study (6th funding period) is supported by the National Institute on Aging of the National Institutes of Health under award number U19AG063720 to M. Brooks [contact; University of Pittsburgh], S. Burnett-Bowie, C. Derby, M. Hedderson, I. Janssen, A. Karlamangla, C. Karvonen-Gutierrez, D. McConnell, R. Thurston & L.E. Waetjen.
Estimating Cardiorespiratory Fitness in Population-Based Research
The American College of Sports Medicine (ACSM) Paffenbarger-Blair Fund for Epidemiological Research on Physical Activity is an early-career grant that encourages researchers early in their career to become involved with physical activity epidemiology. Applications may focus on observational studies of physical activity and health outcomes, or on randomized controlled trials that are clearly focused on physical activity and important public health issues.
Please visit the ACSM website for more information (ACSM Research Grants).
The overall goal of this study is to examine the validity and clinical utility of the 6-Minute Walk Test, a submaximal exercise test, to estimate VO2peak using extant data from the Coronary Artery Risk and Development (CARDIA) study; a large population-based cohort of Black and White men and women established in 1985-86. The study aims to develop a prediction equation to estimate VO2peak from the distance ambulated during a 6-Minute Walk Test, examine the validity of the predicted VO2peak, and examine the equivalence of associations between predicted VO2peak and criterion GXT VO2peak with individual cardiovascular health indicators.
Funding Source. This study is supported by the American College of Sports Medicine Grant to B. Hornikel.
