Publications

2019 Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline.  Aging Cell.  18. 2019
10.1111/acel.13005 
2019 Cause or casualty: The role of mitochondrial DNA in aging and age- associated disease.  Biochim Biophys ActaMol Basis Dis. 2019
2018 Proline- and arginine-rich peptides as flexible allosteric modulators of human proteasome activity.  Journal of Medicinal Chemistry.  2018
2017 Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan..  Aging Cell.  2017
2015 Fibroblasts From Longer-Lived Species of Primates, Rodents, Bats, Carnivores, and Birds Resist Protein Damage J Gerontol A Biol Sci Med Sci. 2015 2015
10.1093/gerona/glu115 
2015 Mouse and primate lifespan is correlated with immunoproteasome expression.  Journal of Clinical Investigation.  2015
2013 Oxidative Stress Adaption with Acute, Chronic and Repeated Stress.  Free Radical Biology and Medicine.  2013
2013 A Conserved Role for the 20S Proteasome and Nrf2 Transcription Factor in Oxidative-Stress Adaptation in Mammals, C. elegans and D. melanogaster. Journal of Experimental  Biology.2013
2012 Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins.  Archives of Biochemistry and Biophysics.  523:181-190. 2012
10.1016/j.abb.2012.04.018 
2012 A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis.  Free Radical Biology and Medicine.  52:239-246. 2012
10.1016/j.freeradbiomed.2011.08.018 
2012 Degradation of damaged proteins: the main function of the 20S proteasome.  Progress in Molecular Biology and Translational Science.  109. 2012
2012 Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress.  Journal of Biological Chemistry.  23:10021-31. 2012
2011 HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress.  Free Radical Biology and Medicine.  51:1355-1364. 2011
10.1016/j.freeradbiomed.2011.06.015 
2010 The immunoproteasome, the 20S proteasome, and the PA28aß proteasome regulator are oxidative stress-adaptive proteolytic complexes..  Biochemical Journal.  51:585-594. 2010
2009 Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster.  BMC Genomics.  10:124-124. 2009
10.1186/1471-2164-10-124 

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