Welcome to the

Pickering
Aging Lab

Central research question

Our lab is interested in studying aging and Alzheimer’s disease with goal of making people happy healthier for longer.
Our primary focus is the impact of proteostasis or protein regulation on aging and neurodegeneration. As we get older we experience an imbalance between the rate at which proteins are synthesized and the rate at which they are degraded this imbalance leads to this imbalance drives many age-related deficits. Our group is interested in understanding and correcting proteostatic deficits to increase health and healthspan.

Recent Publications

Chocron ES, Munkácsy E, Kim HS, Karpowicz P, Jiang N, Van Skike CE, DeRosa N, Banh AQ, Palavicini JP, Wityk P, Kalinowski L, Galvan V, Osmulski PA, Jankowska E, Gaczynska M, Pickering AM. Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models. Science Advances. 2022 

Chocron ES, Mdaki K, Jiang N, Cropper J, Pickering AM. Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function. Communications Biology. 2022 

Kim HS, Son J, Lee D, Tsai J, Wang D, Chocron ES, Jeong S, Kittrell P, Murchison CF, Kennedy RE, Tobon A, Jackson CE, Pickering AM. Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset. BMC Neurology. 2022 

 

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