Postdoctoral training opportunities
Positions are available for ambitious and outstanding postdocs to participate in studies of molecular mechanisms and therapy development for malignant brain tumors.
Our goal is to understand the mechanisms of therapeutic resistance in malignant brain tumors (e.g., glioblastoma, medulloblastoma, pediatric high-grade glioma, etc.). Brain tumor cells can undergo flexible transformation and acquire resistance to treatment when exposed to radiation or chemotherapy. However, the mechanism is still largely unknown. Our group has established several models to observe the changes of brain tumor cells during repeated irradiation. We are analyzing the mechanism of adaptive resistance to develop new treatment for malignant brain tumors.
In addition, our group is actively conducting research using humanized mice in collaboration with the Kamata lab at UAB. Humanized mice are models that reproduce the human immune system in mice. By transplanting human brain tumor cells into these mice, the relationship between human tumor cells and human immune cells can be analyzed in mice. Our group created a humanized mouse brain tumor model, and by using this new model, we are analyzing the resistance mechanism that could not be elucidated by conventional models.
Reference:
- Osuka S, J Clin Invest. 131(6):e136098, 2021
- Zhu D, Osuka S, Cancer Cell. 11;33(6):1004-1016, 2018.
- Osuka S, J Clin Invest. 1;127(2):415-426, 2017.
Complete List of Published Work
The laboratory is located in the NCI-designated O’Neal Comprehensive Cancer Center, which provides an outstanding and stimulating scientific environment with multiple supportive core facilities. UAB is one of the nation’s leading cancer research and treatment centers and is committed to the development and success of outstanding postdoctoral scientists. The Office of Postdoctoral Education at UAB provides mentoring and career guidance and postdocs benefit from a faculty mentoring committee that guides their training and progress. Postdoc scholars qualify for UAB sponsored benefits, including health, life, and other insurances.
Candidates should have a MD or PhD or equivalent in the biomedical sciences (molecular biology, biochemistry, cancer biology, drug discovery and related disciplines), mastery of oral and written English. Prior experience with animal models of cancer are an advantage. The initial appointment is set for 12 months, followed by annual renewal based on mutual agreement. Salary is commensurate with experience and Institutional guidelines.
Interested applicants should send application materials by email to sosuka@uabmc.edu. The application materials should include: a current CV with names and contact information of three references and a brief statement of career goals, research background and interests.
