Welcome to the Osuka Lab!
Our laboratory focuses on understanding the mechanisms of therapeutic resistance in malignant brain tumors (e.g., glioblastoma, medulloblastoma, pediatric high-grade glioma, etc.). The treatment of malignant brain tumors includes surgery, chemotherapy, and radiotherapy. However, tumor cells are strongly resistant to treatment, and it is difficult to prevent recurrence with current treatments. Brain tumor cells can undergo a flexible transformation and acquire resistance to treatment when exposed to radiation or chemotherapy. However, the mechanism is still largely unknown. Our group has established several models to observe the changes in brain tumor cells during repeated irradiation. We are analyzing the mechanism of adaptive resistance to develop new treatments for malignant brain tumors.
The laboratory is located in the NCI-designated O’Neal Comprehensive Cancer Center, which provides an outstanding and stimulating scientific environment with multiple supportive core facilities. UAB is one of the nation’s leading cancer research and treatment centers and is committed to the development and success of outstanding scientists and students.
