Publications

[2024]

• Leitzel O, Francis-Oliveira J, Khedr SM, Ariste L, Robel S, Kano S, Arrant A, Niwa M*. Adolescent stress accelerates postpartum novelty recognition impairment in 5xFAD mice. Front Neurosci. 2024 May 15;18:1366199. doi: 10.3389/fnins.2024.1366199.
• Niwa M*, Lockhart S, Wood DJ, Yang K, Francis-Oliveira J, Kin K, Ahmed A, Wand GS, Kano S, Payne JL, Sawa A. Prolonged HPA axis dysregulation in postpartum depression associated with adverse early life experiences during development: a cross-species translational study. Nat Ment Health. 2024;2(5):593-604. Epub 20240411. doi: 10.1038/s44220-024-00217-1. PubMed PMID: 38736646; PMCID: PMC11087073. https://rdcu.be/dEtHd. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087073/. —This article was featured in UAB News.
• Ramos A, Ishizuka K, Hayashida A, Namkung H, Hayes LN, Srivastava R, Zhang M, Kariya T, Elkins N, Palen T, Carloni E, Tsujimura T, Calva C, Ikemoto S, Rais R, Slusher BS, Niwa M, Saito A, Saitoh T, Takimoto E, Sawa A. Nuclear GAPDH in cortical microglia mediates stress-induced cognitive flexibility. Mol Psychiatry. 2024 Oct;29(10):2967-2978. doi: 10.1038/s41380-024-02553-1. Epub 2024 Apr 13.PMID: 38615102.
• Fry BR, Fex V, Sawa A, Niwa M, Johnson AW. The role of midbrain dopamine cells projecting to the insular cortex in mediated performance: Implications for animal models of reality testing. Behav Neurosci. 2024;138(3):164-177. doi: 10.1037/bne0000580. PubMed PMID: 38934920.

[2023]

• Kin K, Francis-Oliveira J, Kano SI, Niwa M*. Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway in mice. Nat Commun. 2023 May 23;14(1):2975. doi: 10.1038/s41467-023-38799-6. PMID: 37221211.—This article was featured in UAB News and Inscopix blog.
• Macpherson T, Niwa M, Morishita H, Hikida T. Editorial: Circuit, molecular, and developmental mechanisms in decision-making behavior. Frontiers in Neuroscience. Front Neurosci. 2023 Apr 25;17:1192237. doi: 10.3389/fnins.2023.1192237. PMID: 37179551
• Namkung H, Yukitake H, Fukudome D, Lee BJ, Tian M, Ursini G, Saito A, Lam S, Kannan S, Srivastava R, Niwa M, Sharma K, Zandi P, Jaaro-Peled H, Ishizuka K, Chatterjee N, Huganir RL, Sawa A. The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder. Neuron. 2023 Jan 18;111(2):220-235.e9. doi: 10.1016/j.neuron.2022.10.031. Epub 2022 Nov 14.PMID: 36379214.
• Kim SH, An K, Namkung H, Saito A, Rannals MD, Moore JR, Mihaljevic M, Saha S, Oh S, Kondo MA, Ishizuka K, Yang K, Maher BJ, Niwa M, Sawa A. Anterior Insula-Associated Social Novelty Recognition: Pivotal Roles of a Local Retinoic Acid Cascade and Oxytocin Signaling. Am J Psychiatry. 2023 Apr 1;180(4):305-317. doi: 10.1176/appi.ajp.21010053. Epub 2022 Sep 21.PMID: 36128683

[2022]

• Francis-Oliveira J, Leitzel O, Niwa M*. Are the Anterior and Mid-Cingulate Cortices Distinct in Rodents? Front Neuroanat. 2022;16:914359. doi: 10.3389/fnana.2022.914359. PMID: 35721461. 
• Kin K, Gaini R, Niwa M*. Effects of social isolation throughout the lifespan on behaviors and related neuroendocrine functions in rodents. In: Della Sala, S. (Ed.), Elsevier, Encyclopedia of Behavioral Neuroscience, Second Edition. 2022;1:360-371. https://dx.doi.org/10.1016/B978-0-12-819641-0.00090-6.
• Niwa M*. A research life with diversity. Bulletin of the Japanese Society for Neurochemistry. 2022; 61(1): 1-5. doi:10.11481/topics175.

[2021]

• Fu X, Shah AP, Keighron J, Mou TM, Ladenheim B, Alt J, Fukudome D, Niwa M, Tamashiro KL, Tanda G, Sawa A, Cadet JL, Rais R, Baraban JM. Elevated body fat increases amphetamine accumulation in brain: evidence from genetic and diet-induced forms of adiposity. Transl Psychiatry. 2021 Aug 14;11(1):427. doi: 10.1038/s41398-021-01547-9.PMID: 34392304.
• Mejias R, Rodriguez-Gotor JJ, Niwa M, Krasnova IN, Adamczyk A, Han M, Thomas GM, Xi ZX, Huganir RL, Pletnikov MV, Sawa A, Cadet JL, Wang T. Increased novelty-induced locomotion, sensitivity to amphetamine, and extracellular dopamine in striatum of Zdhhc15-deficient mice. Transl Psychiatry. 2021 Jan 18;11(1):65. doi: 10.1038/s41398-020-01194-6.PMID: 33462194.

[2020]

• Takayanagi Y, Ishizuka K, Laursen TM, Yukitake H, Yang K, Cascella NG, Ueda S, Sumitomo A, Narita Z, Horiuchi Y, Niwa M, Taguchi A, White MF, Eaton WW, Mortensen PB, Sakurai T, Sawa A. From population to neuron: exploring common mediators for metabolic problems and mental illnesses. Mol Psychiatry. 2021 Aug;26(8):3931-3942. doi: 10.1038/s41380-020-00939-5. Epub 2020 Nov 10.PMID: 33173197.
• Hikida T, Morita M, Kuroiwa M, Macpherson T, Shuto T, Sotogaku N, Niwa M, Sawa A, Nishi A. Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice. Neurosci Res. 2020 Feb;151:38-45. doi: 10.1016/j.neures.2019.02.007. Epub 2019 Mar 1. PubMed PMID: 30831136; PubMed Central PMCID: PMC6717686.
• Fry BR, Russell N, Gifford R, Robles CF, Manning CE, Sawa A, Niwa M, Johnson AW. Assessing Reality Testing in Mice Through Dopamine-Dependent Associatively Evoked Processing of Absent Gustatory Stimuli. Schizophr Bull. 2020 Jan 4;46(1):54-67. doi: 10.1093/schbul/sbz043. PubMed PMID: 31150554; PubMed Central PMCID: PMC6942166.
• Kano SI, Hodgkinson CA, Jones-Brando L, Eastwood S, Ishizuka K, Niwa M, Choi EY, Chang DJ, Chen Y, Velivela SD, Leister F, Wood J, Chowdari K, Ducci F, Caycedo DA, Heinz E, Newman ER, Cascella N, Mortensen PB, Zandi PP, Dickerson F, Nimgaonkar V, Goldman D, Harrison PJ, Yolken RH, Sawa A. Host-parasite interaction associated with major mental illness. Mol Psychiatry. 2020 Jan;25(1):194-205. doi: 10.1038/s41380-018-0217-z. Epub 2018 Aug 20. PubMed PMID: 30127472; PubMed Central PMCID: PMC6382596.
• Niwa M*. My research life beyond the common sense. Experimental Medicine. 38(4): 646-648 (2020).

[2019]

• Yang K, Kondo MA, Jaaro-Peled H, Cash-Padgett T, Kano SI, Ishizuka K, Pevsner J, Tomoda T, Sawa A, Niwa M*. The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood. Schizophr Res. 2019 Aug;210:149-156. doi: 10.1016/j.schres.2019.05.032. Epub 2019 Jun 13. PubMed PMID: 31204062.

[2018]

• Sumitomo A, Yukitake H, Hirai K, Horike K, Ueta K, Chung Y, Warabi E, Yanagawa T, Kitaoka S, Furuyashiki T, Narumiya S, Hirano T, Niwa M, Sibille E, Hikida T, Sakurai T, Ishizuka K, Sawa A, Tomoda T. Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Hum Mol Genet. 2018 Sep 15;27(18):3165-3176. doi: 10.1093/hmg/ddy219. PubMed PMID: 29893844; PubMed Central PMCID: PMC6121199.
• Fukudome D, Hayes LN, Faust TE, Foss CA, Kondo MA, Lee BJ, Saito A, Kano SI, Coughlin JM, Kamiya A, Pomper MG, Sawa A, Niwa M*. Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances. Schizophr Res. 2018 Jul;197:492-497. doi: 10.1016/j.schres.2018.01.015. Epub 2018 Feb 3. PubMed PMID: 29398205; PubMed Central PMCID: PMC6470041.
• Lockhart S, Sawa A, Niwa M*. Developmental trajectories of brain maturation and behavior: Relevance to major mental illnesses. J Pharmacol Sci. 2018 May;137(1):1-4. doi: 10.1016/j.jphs.2018.04.008. Epub 2018 May 3. Review. PubMed PMID: 29773518.

[2017]

• Dohi E, Choi EY, Rose IVL, Murata AS, Chow S, Niwa M, Kano SI. Behavioral Changes in Mice Lacking Interleukin-33. eNeuro. 2017 Nov-Dec;4(6). doi: 10.1523/ENEURO.0147-17.2017. eCollection 2017 Nov-Dec. PubMed PMID: 29379874; PubMed Central PMCID: PMC5788055.
• Matsumoto Y, Niwa M*, Mouri A, Noda Y, Fukushima T, Ozaki N, Nabeshima T. Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice. Psychopharmacology (Berl). 2017 Oct;234(20):3055-3074. doi: 10.1007/s00213-017-4704-8. Epub 2017 Jul 29. PubMed PMID: 28756461.
• Segal-Gavish H, Gazit N, Barhum Y, Ben-Zur T, Taler M, Hornfeld SH, Gil-Ad I, Weizman A, Slutsky I, Niwa M, Kamiya A, Sawa A, Offen D, Barzilay R. BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interaction. Hum Mol Genet. 2017 Jul 1;26(13):2462-2471. doi: 10.1093/hmg/ddx139. PubMed PMID: 28402427; PubMed Central PMCID: PMC6251614.
• Mouri A, Noda Y, Niwa M, Matsumoto Y, Mamiya T, Nitta A, Yamada K, Furukawa S, Iwamura T, Nabeshima T. The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization. Behav Brain Res. 2017 Jun 30;329:157-165. doi: 10.1016/j.bbr.2017.04.052. Epub 2017 May 1. PubMed PMID: 28472632.

[2016]

• Niwa M, Cash-Padgett T, Kubo KI, Saito A, Ishii K, Sumitomo A, Taniguchi Y, Ishizuka K, Jaaro-Peled H, Tomoda T, Nakajima K, Sawa A, Kamiya A. DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1. Mol Psychiatry. 2016 Nov;21(11):1488-1489. doi: 10.1038/mp.2016.154. Epub 2016 Sep 6. PubMed PMID: 27595595; PubMed Central PMCID: PMC5472474.
• Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T. Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning. Mol Neuropsychiatry. 2016 Oct;2(3):124-132. doi: 10.1159/000447970. Epub 2016 Jul 21. PubMed PMID: 27867937; PubMed Central PMCID: PMC5109995.
• Niwa M, Lee RS, Tanaka T, Okada K, Kano S, Sawa A. A critical period of vulnerability to adolescent stress: epigenetic mediators in mesocortical dopaminergic neurons. Hum Mol Genet. 2016 Apr 1;25(7):1370-81. doi: 10.1093/hmg/ddw019. Epub 2016 Jan 28. PubMed PMID: 26908623; PubMed Central PMCID: PMC4787906.

[2015]

• Seshadri S, Faust T, Ishizuka K, Delevich K, Chung Y, Kim SH, Cowles M, Niwa M, Jaaro-Peled H, Tomoda T, Lai C, Anton ES, Li B, Sawa A. Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex. Nat Commun. 2015 Dec 11;6:10118. doi: 10.1038/ncomms10118. PubMed PMID: 26656849; PubMed Central PMCID: PMC4682104.
• Rais R, Wozniak K, Wu Y, Niwa M, Stathis M, Alt J, Giroux M, Sawa A, Rojas C, Slusher BS. Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration. PLoS One. 2015;10(7):e0131861. doi: 10.1371/journal.pone.0131861. eCollection 2015. PubMed PMID: 26151906; PubMed Central PMCID: PMC4494705.
• Ueda S, Niwa M, Hioki H, Sohn J, Kaneko T, Sawa A, Sakurai T. Sequence of Molecular Events during the Maturation of the Developing Mouse Prefrontal Cortex. Mol Neuropsychiatry. 2015 Jul;1(2):94-104. doi: 10.1159/000430095. Epub 2015 Jun 9. PubMed PMID: 26457295; PubMed Central PMCID: PMC4596535.

[2014]

• Niwa M*. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science Japan. 1: 13 (2014).
• Nabeshima T, Niwa M*. Adolescent stress leads to neuronal disturbance via epigenetic control. IGAKUNOAYUMI. 249(2):179 (2014).

[2013]

• Jaaro-Peled H, Niwa M, Foss CA, Murai R, de Los Reyes S, Kamiya A, Mateo Y, O’Donnell P, Cascella NG, Nabeshima T, Guilarte TR, Pomper MG, Sawa A. Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging. Hum Mol Genet. 2013 Apr 15;22(8):1574-80. doi: 10.1093/hmg/ddt007. Epub 2013 Jan 11. PubMed PMID: 23314019; PubMed Central PMCID: PMC3605832.
• Niwa M, Jaaro-Peled H, Tankou S, Seshadri S, Hikida T, Matsumoto Y, Cascella NG, Kano S, Ozaki N, Nabeshima T, Sawa A. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science. 2013 Jan 18;339(6117):335-9. doi: 10.1126/science.1226931. PubMed PMID: 23329051; PubMed Central PMCID: PMC3617477.–This article was featured in: 1) Science 339: 279-280 (2013). Perspectives. Neuroscience: Hormones and the Social Brain. McEwen BS. 2) Sci Signal 259: 23 (2013). Defeat, Distress, and Glucocorticoids. Stern PR. 3) Nat Rev Endocrinol 9: 125 (2013). Research Highlights. Basic research: From stress to social behavior-glucocorticoids and dopaminergic circuits pave the way. Osório J.
• Niwa M, Nabeshima T, Sawa A. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Life science newly-arrived review: archives/6492 (2013).

[2012]

• Mouri A, Koseki T, Narusawa S, Niwa M, Mamiya T, Kano S, Sawa A, Nabeshima T. Mouse strain differences in phencyclidine-induced behavioural changes. Int J Neuropsychopharmacol. 2012 Jul;15(6):767-79. doi: 10.1017/S146114571100085X. Epub 2011 Jun 9. PubMed PMID: 21733237; NIHMSID:NIHMS455167.
• Niwa M*. Establishment and analysis of animal models in psychiatric disorders research-from the point of view of genetic-environmental interactions. JPN J Mol Psychiatry. 13(1): 28-35 (2012).
• Matsumoto Y, Niwa M*, Mouri A, Ozaki N, Nabeshima T. Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders. Nihon Shinkei Seishin Yakurigaku Zasshi. 2012 Apr;32(2):109-11. PubMed PMID: 22708268.

[2011]

• Kano S, Nwulia E, Niwa M, Chen Y, Sawa A, Cascella N. Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia. Neurosci Res. 2011 Nov;71(3):289-93. doi: 10.1016/j.neures.2011.07.1818. Epub 2011 Jul 27. PubMed PMID: 21801761.
• Niwa M, Matsumoto Y, Mouri A, Ozaki N, Nabeshima T. Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders. Int J Neuropsychopharmacol. 2011 May;14(4):459-77. doi: 10.1017/S1461145710001239. Epub 2010 Oct 18. PubMed PMID: 20950517.
• Niwa M, Nabeshima T. Roles of a novel molecule ‘shati’ in the development of methamphetamine-induced dependence. Curr Neuropharmacol. 2011 Mar;9(1):104-8. doi: 10.2174/157015911795017362. PubMed PMID: 21886572; PubMed Central PMCID: PMC3137161.

[2010]

• Lipina TV, Niwa M, Jaaro-Peled H, Fletcher PJ, Seeman P, Sawa A, Roder JC. Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia. Genes Brain Behav. 2010 Oct;9(7):777-89. doi: 10.1111/j.1601-183X.2010.00615.x. Epub 2010 Aug 12. PubMed PMID: 20618446.
• Alkam T, Nitta A, Furukawa-Hibi Y, Niwa M, Mizoguchi H, Yamada K, Nabeshima T. Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase. Behav Brain Res. 2010 Jul 11;210(2):184-90. doi: 10.1016/j.bbr.2010.02.028. Epub 2010 Feb 19. PubMed PMID: 20171988.
• Lu P, Mamiya T, Lu L, Mouri A, Niwa M, Kim HC, Zou LB, Nagai T, Yamada K, Ikejima T, Nabeshima T. Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behav Brain Res. 2010 Mar 5;207(2):387-93. doi: 10.1016/j.bbr.2009.10.024. Epub 2009 Oct 24. PubMed PMID: 19857526.
• Niwa M, Kamiya A, Murai R, Kubo K, Gruber AJ, Tomita K, Lu L, Tomisato S, Jaaro-Peled H, Seshadri S, Hiyama H, Huang B, Kohda K, Noda Y, O’Donnell P, Nakajima K, Sawa A, Nabeshima T. Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron. 2010 Feb 25;65(4):480-9. doi: 10.1016/j.neuron.2010.01.019. PubMed PMID: 20188653; PubMed Central PMCID: PMC3084528. Video Abstract.—This article was featured in: 1) Nature Medicine. 16: 384-385 (2010).  Research Highlights.  Neuroscience:   Schizophrenia in utero.  López JC.  2) Nature Reviews Neuroscience. 11: 224-225 (2010).  Research Highlights.  Psychiatric disorders: From the cradle.  Bodo C.  3) Neuron. 65(4): 437-439 (2010).  Previews.   Now you see it, now you don’t–closing in on allostasis and developmental basis of psychiatric disorders.  Thompson BL, Pat Levitt P.
• Ibi D, Nagai T, Koike H, Kitahara Y, Mizoguchi H, Niwa M, Jaaro-Peled H, Nitta A, Yoneda Y, Nabeshima T, Sawa A, Yamada K. Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Behav Brain Res. 2010 Jan 5;206(1):32-7. doi: 10.1016/j.bbr.2009.08.027. Epub 2009 Aug 28. PubMed PMID: 19716847; PubMed Central PMCID: PMC2846597.
• Ebihara S, Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Matsuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa A, Abe K, Yoshimura T, Nabeshima T. Usp46, encoding a ubiquitin specific peptidase, is a quantitative trait gene underlying ‘‘behavioral despair’’ in mice. Sleep Biol Rhythms. 2010; 8:114-119. doi: 10.1111/j.1479-8425.2010.00435.x.

[2009]

• Lu P, Mamiya T, Lu LL, Mouri A, Niwa M, Hiramatsu M, Zou LB, Nagai T, Ikejima T, Nabeshima T. Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice. J Pharmacol Exp Ther. 2009 Oct;331(1):319-26. doi: 10.1124/jpet.109.155069. Epub 2009 Jul 28. PubMed PMID: 19638571.
• Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Masuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa A, Abe K, Yoshimura T, Nabeshima T, Ebihara S. Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Nat Genet. 2009 Jun;41(6):688-95. doi: 10.1038/ng.344. Epub 2009 May 24. PubMed PMID: 19465912.
• Lu L, Mamiya T, Lu P, Niwa M, Mouri A, Zou LB, Nagai T, Hiramatsu M, Nabeshima T. The long-lasting effects of cross-fostering on the emotional behavior in ICR mice. Behav Brain Res. 2009 Mar 2;198(1):172-8. doi: 10.1016/j.bbr.2008.10.031. Epub 2008 Nov 6. PubMed PMID: 19027040.
• Niwa M, Ozaki N, Nabeshima T. Approach for investigation of molecules and novel therapeutic drugs related to methamphetamine-induced dependence. JPN J Mol Psychiatry. 9(1): 2-11 (2009).

[2008]

• Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K, Nabeshima T. A novel molecule ‘shati’ increases dopamine uptake via the induction of tumor necrosis factor-alpha in pheochromocytoma-12 cells. J Neurochem. 2008 Dec;107(6):1697-708. doi: 10.1111/j.1471-4159.2008.05738.x. Epub 2008 Nov 5. PubMed PMID: 19014384.
• Niwa M, Yan Y, Nabeshima T. Genes and molecules that can potentiate or attenuate psychostimulant dependence: relevance of data from animal models to human addiction. Ann N Y Acad Sci. 2008 Oct;1141:76-95. doi: 10.1196/annals.1441.024. Review. PubMed PMID: 18991952.
• Cen X, Nitta A, Ibi D, Zhao Y, Niwa M, Taguchi K, Hamada M, Ito Y, Ito Y, Wang L, Nabeshima T. Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. Mol Psychiatry. 2008 Apr;13(4):349, 451-63. doi: 10.1038/sj.mp.4002132. Epub 2008 Jan 15. PubMed PMID: 18195717. Cover Art.
• Cen X, Nitta A, Ibi D, Zhao Y, Niwa M, Taguchi K, Hamada M, Ito Y, Ito Y, Wang L, Nabeshima T. Piccolo regulates dopamine transporter internalization via PIP(2). Mol Psychiatry. 2008; 13:349.
• Niwa M, Nabeshima T. An inducer for GDNF and TNF-α could be a novel therapeutic agent for drug dependence. JPN J Mol Psychiatry. 8(2): 84-87 (2008).

[2007]

• Niwa M, Nitta A, Yamada Y, Nakajima A, Saito K, Seishima M, Noda Y, Nabeshima T. Tumor necrosis factor-alpha and its inducer inhibit morphine-induced rewarding effects and sensitization. Biol Psychiatry. 2007 Sep 15;62(6):658-68. doi: 10.1016/j.biopsych.2006.10.009. Epub 2007 Jan 9. PubMed PMID: 17217924. Cover Art.
• Mizoguchi H, Yamada K, Mouri A, Niwa M, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y, Nabeshima T. Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implications for dopamine receptor down-regulation and dopamine release. J Neurochem. 2007 Sep;102(5):1548-1560. doi: 10.1111/j.1471-4159.2007.04623.x. Epub 2007 May 1. PubMed PMID: 17472698.
• Niwa M, Nitta A, Mizoguchi H, Ito Y, Noda Y, Nagai T, Nabeshima T. A novel molecule “shati” is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference. J Neurosci. 2007 Jul 11;27(28):7604-15. doi: 10.1523/JNEUROSCI.1575-07.2007. PubMed PMID: 17626222; PubMed Central PMCID: PMC6672622.
• Yan Y, Yamada K, Niwa M, Nagai T, Nitta A, Nabeshima T. Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial-cell-line-derived neurotrophic factor mutant mice. FASEB J. 2007 Jul;21(9):1994-2004. doi: 10.1096/fj.06-7772com. Epub 2007 Mar 13. PubMed PMID: 17356005.
• Niwa M, Nitta A, Yamada K, Nabeshima T. The roles of glial cell line-derived neurotrophic factor, tumor necrosis factor-alpha, and an inducer of these factors in drug dependence. J Pharmacol Sci. 2007 Jun;104(2):116-21. doi: 10.1254/jphs.cp0070017. Epub 2007 May 31. PubMed PMID: 17538232.
• Niwa M, Nitta A, Shen L, Noda Y, Nabeshima T. Involvement of glial cell line-derived neurotrophic factor in inhibitory effects of a hydrophobic dipeptide Leu-Ile on morphine-induced sensitization and rewarding effects. Behav Brain Res. 2007 Apr 16;179(1):167-71. doi: 10.1016/j.bbr.2007.01.026. Epub 2007 Feb 3. PubMed PMID: 17331595.
• Niwa M, Nitta A, Yamada Y, Nakajima A, Saito K, Seishima M, Shen L, Noda Y, Furukawa S, Nabeshima T. An inducer for glial cell line-derived neurotrophic factor and tumor necrosis factor-alpha protects against methamphetamine-induced rewarding effects and sensitization. Biol Psychiatry. 2007 Apr 1;61(7):890-901. doi: 10.1016/j.biopsych.2006.06.016. Epub 2006 Oct 13. PubMed PMID: 17046726.
• Mizoguchi H, Yamada K, Niwa M, Mouri A, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y, Nabeshima T. Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient mice. J Neurochem. 2007 Mar;100(6):1579-88. doi: 10.1111/j.1471-4159.2006.04288.x. PubMed PMID: 17348864.
• Niwa M, Nabeshima T. Discovery of functional molecules related to drug dependence. Med Bio. 12-13 (2007).
• Niwa M*. The role of orexin in the development of drug dependence. Farumashia. 43(1): 60-61 (2007).

[2004]

• Mouri A, Noda Y, Niwa M, Nabeshima T. The psychological dependence and neurotoxicity induced by MDMA.  IGAKUNOAYUMI. 209(2): 120-121 (2004).

[2002]

• Kitajima M, Niwa M, Yanagisawa C, Takayama H, Sudo H, Saito K, Aimi N. Camptothecin-related alkaloids from culture medium of hairy roots of Ophiorrihiza pumila. Natural Med. 2002; 56:275.