There are two possible outcomes: If the result confirms the hypothesis you have made a measurement, if the result is contrary, you have made a discovery.  Enrico Fermi

Pubmed Link to Complete Bibliography

Current Active Preprints:
HuR -dependent SOD2 protein synthesis is an early adaptation of ovarian cancer cells in response to anchorage independence Yeon Soo Kim, Jaclyn E. Welles, Priscilla W. Tang, Zaineb Javed, Amal T. Elhaw, Karthikeyan Mythreye, Scot R.Kimball, Nadine Hempel.
bioRxiv 2021.02.19.432010; doi:
Eduardo Listik ,Ben Horst ,Alex Seok Choi, Nam. Y. Lee,Balázs Győrffy, Karthikeyan Mythreye.
A bioinformatic analysis of the inhibin-betaglycan-endoglin/CD105 network reveals prognostic value in multiple solid tumors. PLOS ONE 16(4): e0249558.

Asha Kumari, Zainab Shonibre, Mehri Monavarian, Rebecca C. Arend, Nam Y. Lee, Gareth J Inman and Karthikeyan Mythreye. 
TGFβ signaling networks in ovarian cancer progression and plasticity.Clinical & Experimental Metastasis (2021)
Tasmia Ahmed, Karthikeyan Mythreye and Nam Y Lee*. 
Strength and duration of GIPC-dependent signaling networks as determinants in cancer. Neoplasia 2020 Dec 24;23(2):181-188. doi: 10.1016/j.neo.2020.12.004

Yeon Soo Kim, Piyushi Gupta-Vallur, Victoria M. Jones, Beth L. Worley, Sara Shimko, Dong-Hui Shin, LaTaijah C. Crawford, Chi-Wei Chen, Katherine M. Aird, Thomas Abraham, Trevor G. Shepherd, Joshua I.Warrick,  Nam Y. Lee, Rebecca Phaeton, Karthikeyan Mythreye*, Nadine Hempel*. 
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells. Oncogene 2020 Feb;39(8):1619-1633doi: 10.1038/s41388-019-1097-7. Epub 2019 Nov 13 * Co-corresponding authors

Beth L. Worley, Yeon Soo Kim, Jennifer Mardini, Rameez Zaman, Kelly Leon, Piyushi Gupta Vallur, Asvelt Nduwumwami, Joshua I. Warrick, Patrick F. Timmins, Joshua P. Kesterson, Rébécca Phaëton, Nam Y. Lee, Vonn Walter, Lauren Endres, Karthikeyan Mythreye, Katherine M. Aird, Nadine Hempel. GPX3 supports ovarian cancer progression by manipulating the extracellular redox environment. Redox Biology 2019 Jul;25:101051. doi: 10.1016/j.redox.2018.11.009. Epub 2018 Nov 17 
Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB. 
CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases. Cancer Res. 2018 Sep 5. pii: canres.1583.2018. doi: 10.1158/0008-5472.CAN-18-1583.

Varadaraj A, Magdaleno C, Mythreye K
Deoxycholate Fractionation of Fibronectin (FN) and Biotinylation Assay to Measure Recycled FN Fibrils in Epithelial Cells. Bio Protoc. 2018 Aug 20;8(16). pii: e2972. doi: 10.21769/BioProtoc.2972

Serrao A, Jenkins L.M, Chumanevich.A, Horst B,Liang J, Gatza M.L, Lee N.Y, Roninson I.B,Broude E.V, and Mythreye K. 
Mediator kinase CDK8/CDK19 drives YAP1 dependent BMP4 induced EMT in cancer. Oncogene. 2018 May 21. doi: 10.1038/s41388-018-0316-y. [Epub ahead of print]

Shah N, Kumar S, Zaman N, Pan CC, Bloodworth JC, Lei W, Streicher JM, Hempel N, Mythreye K, Lee NY. 
TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth. Nat Commun. 2018 Apr 27;9(1):1696. doi: 10.1038/s41467-018-04121-y.

Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K. 
Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis.  Cancer Res. 2018 Mar 13. pii: canres.2316.2017. doi: 10.1158/0008-5472.CAN-17-2316. 
Jenkins LM, Horst B, Lancaster CL, Mythreye K. 
Dually modified transmembrane proteoglycans in development and disease.Cytokine Growth Factor Rev. 2018 Feb;39:124-136. doi: 10.1016/j.cytogfr.2017.12.003. Epub 2017 Dec 22. Review.  Note: Cover Article.

Kim YS, Gupta Vallur P, Phaëton R, Mythreye K, Hempel N. 
Insights into the Dichotomous Regulation of Sod2 in Cancer. Antioxidants (Basel). 2017 Nov 3;6(4). pii: E86. doi: 10.3390/antiox6040086. Review.

Varadaraj A, Jenkins LM, Singh P,Chanda A, Snider J, Lee NY, Amsalem-Zafran AR, Ehrlich M, Henis YI, Mythreye K
TGF-β triggers rapid fibrillogenesis via a novel TβRII dependent fibronectin trafficking mechanism" Mol Biol Cell. 2017 Mar 15. pii: mbc.E16-08-0601. doi: 10.1091/mbc.E16-08-0601 Note: F1000 prime recommended. 
Jenkins LM, Singh P, Varadaraj A, Lee NY, Shah S, Flores HV, O'Connell K, Mythreye K
Altering the proteoglycan state of TβRIII /Betaglycan modulates canonical Wnt/β-catenin signaling. J Biol Chem. 2016 Dec 2;291(49):25716-25728. Epub 2016 Oct 26.

Kumar S, Pan CC, Shah N, Wheeler SE, Hoyt KR, Hempel N, Mythreye K, Lee NY. 
Activation of mitofusin2 by Smad2-RIN1 complex during mitochondrial fusion. Mol Cell. 2016 May 19;62(4):520-31. doi: 10.1016/j.molcel.2016.04.010. Epub 2016 May 12.

Pan CC, Shah N, Kumar S, Wheeler SE, Cinti J, Hoyt DG, Beattie CE, An M, Mythreye K, Rakotondraibe LH, Lee NY. 
Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy.  Oncotarget. 2016 May 11. doi: 10.18632/oncotarget.9307.
Varadaraj A, Patel P, Serrao A, Bandyopadhay T,Lee NY, Jazaeri AA, Huang Z, Murphy SK, Mythreye K. 
Epigenetic regulation of GDF2 suppresses anoikis in ovarian and breast epithelia. Neoplasia. 2015 Nov; 17(11):826-38. doi: 10.1016/j.neo.2015.11.00

Pan CC, Shah N, Kumar S, Wheeler SE, Cinti J, Hoyt DG, Beattie CE, An M, Mythreye K, Rakotondraibe LH, Lee NY. 
Endoglin regulation of Smad2 function mediates beclin1 expression and endothelial autophagy. J Biol Chem.2015 Jun 12;290(24):14884-92. doi: 10.1074/jbc.M114.630178. Epub 2015 Apr 30.
Other prior select signature papers
Osborne LD, Li GZ, How T, O'Brien ET, Blobe GC, Superfine R, Mythreye K.
TGF-β regulates LARG and GEF-H1 during EMT to impact stiffening response to force and cell invasion. Mol. Biol. Cell 2014 25:22 3528-3540

Knelson EH, Gaviglio AL, Tewari AK, Armstrong MB, Mythreye K*, Blobe GC*
Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma. J Clin Invest. 2013 Nov;123(11):4786-98.(Authorship Note: * equal senior)

Swaminathan V*, Mythreye K*, O'Brien ET, Berchuck A, Blobe GC, Superfine R.
 Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell linesCancer Res. 2011 Aug 1;71(15):5075-80. doi: 10.1158/0008-5472.CAN-11-0247. Epub 2011 Jun 3. (Authorship Note: * equal first)

Mythreye K, Blobe GC 
The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42.Proc Natl Acad Sci U S A. 2009 May 19;106(20):8221-6. doi: 10.1073/pnas.0812879106. Epub 2009 May 1