The lab has published a new paper in PNAS! This work, entitled “Contribution of intraflagellar transport to compartmentalization and maintenance of the photoreceptor cell“, identifies the existence of a sorting mechanism whereby mislocalized rhodopsin can be recruited to and concentrated in extracellular vesicles prior to their release, presumably to protect the cell from adverse effects of protein mislocalization. The study also found that reducing rhodopsin expression significantly delays photoreceptor degeneration in some models of inherited retinal disease associated with rhodopsin mislocalization, suggesting a therapeutic strategy to explore for these conditions.
- Login
- |
- Privacy
- |
- Terms of Use
- |
- © 2025 The University of Alabama at Birmingham
UAB is an Equal Employment/Equal Educational Opportunity Institution dedicated to providing equal opportunities and equal access to all individuals regardless of race, color, religion, ethnic or national origin, sex (including pregnancy), genetic information, age, disability, religion, sexual orientation, gender identity, gender expression, and veteran’s status. As required by Title IX, UAB prohibits sex discrimination in any education program or activity that it operates. Individuals may report concerns or questions to UAB’s Assistant Vice President and Senior Title IX Coordinator. The Title IX notice of nondiscrimination is located at uab.edu/titleix.