*48) Gunnar N. Eastep, Ruba H. Ghanam, Todd J. Green, and Jamil S. Saad (2021). “Structural characterization of HIV-1 matrix mutants implicated in envelope incorporation”. J. Biol. Chem. In press. (PMID: 33485964)
47) Moon H. Nahm*, Terry Brissac, Mogens Kilian, Jiri Vlach, Carlos J. Orihuela, Jamil S. Saad, Feroze Ganaie (2020). “Pneumococci Can Become Virulent by Acquiring a New Capsule From Oral Streptococci”. J. Infect. Dis., 222, 372-380. (PMID: 31605125; PMCID: PMC7457184).
*46) R. Elliot Murphy and Jamil S. Saad (2020). “The interplay between HIV-1 Gag binding to the plasma membrane and Env incorporation”. Viruses, 12, 548-560. (PMID: 32429351; PMCID: PMC7291237)
45) Feroze Ganaie, Jamil S. Saad, Lesley McGee, Andries J. van Tonder, Stephen D. Bentley, Stephanie W. Lo, Rebecca A. Gladstone, Paul Turner, Jeremy D. Keenan, Robert F. Breiman, Moon H. Nahm (2020). “A New Pneumococcal Capsule Type, 10D, Is the 100th Serotype and Has a Large cps Fragment From an Oral Streptococcus”. mBio, 11, E00937-20. (PMID: 32430472)
*44) R. Elliot Murphy, Alexandra B. Samal, Jiri Vlach, Vicente Mas, Peter E. Prevelige, and Jamil S. Saad (2019). “Structural and biophysical characterization of HIV-1 matrix trimer binding to lipid nanodiscs shed light on virus assembly”. J. Biol. Chem. 294, 18600-18612. (PMID: 31640987; PMCID: PMC6901326)
*43) Melanie H. Wong,‡ Alexandra B. Samal,‡ Mike Lee, Jiri Vlach, Nikolai Novikov, Anita Niedziela-Majka, Joy Y. Feng, Dmitry O. Koltun, Katherine M. Brendza, Hyock Joo Kwon, Brian E. Schultz, Roman Sakowicz, Jamil S. Saad,* and Giuseppe A. Papalia* (2019). “The KN-93 molecule inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) activity by binding to Ca2+/CaM”. ‡Authors contributed equally. J. Mol. Biol. 431, 1440-1459. (PMID: 30753871)
42) Uday Tak, Jiri Vlach, Acely Garza-Garcia, Doreen William, Olga Danilchanka, Luis de Carvalho, Jamil S. Saad, and Michael Niederweis (2019). “The tuberculosis necrotizing toxin is an NAD+ and NADP+ glycohydrolase with distinct enzymatic properties”. J. Biol. Chem. 294, 3024-3036. (PMID: 30593509; PMCID: PMC6295721)
*41) Susan M. Watanabe, Gisselle Medina, Gunnar N. Eastep, Ruba H. Ghanam, Jiri Vlach, Jamil S. Saad, and Carol A. Carter (2018). “The matrix domain of the Gag protein from avian sarcoma virus contains a PI(4,5)P2-binding site that targets Gag to the cell periphery”. J. Biol. Chem. 293, 18841-18853. (PMID: 30309982; PMCID: PMC6295721)
*40) Jiri Vlach, Gunnar N. Eastep, Ruba H. Ghanam, Susan M. Watanabe, Carol A. Carter, and Jamil S. Saad (2018). “Structural basis for targeting avian sarcoma virus Gag polyprotein to the plasma membrane for virus assembly”. J. Biol. Chem. 293, 18828-18840. (PMID: 30309983; PMCID: PMC6295720)
– Illustrated on the cover.
*39) Richard E. Murphy, Alexandra B. Samal, Jiri Vlach and Jamil S. Saad (2017). “Solution Structure and Membrane Interaction of the Cytoplasmic Tail of HIV-1 gp41 Protein”. Structure, 25, 1708-1718.e5. (PMID: 29056482; PMCID: PMC5687296)
38) Brady L. Spencer, Jamil S. Saad, Anukul T. Shenoy, Carlos J. Orihuela, and Moon H. Nahm (2017). “Position of O-acetylation within the capsular repeat unit impacts the biological properties of pneumococcal serotypes 33A and 33F”. Infection and Immunity. 85, e00132-17. (PMID: 28438972; PMCID: PMC5478959)
37) Rosanne L. L. Hill, Jiri Vlach, Jamil S. Saad, and Terje Dokland (2017). “Derepression of SaPIbov1 Is Independent of φNM1 Type 2 dUTPase Activity and Is Inhibited by dUTP and dUMP”. J. Mol. Biol. 429, 1570-1580. (PMID: 28400210; PMCID: PMC4738164)
36) K. Aaron Geno, Jamil S. Saad, Moon H. Nahm (2017). “Discovery of novel pneumococcal serotype, 35D, a natural WciG-deficient variant of serotype 35B”. J. Clin. Micro. 55, 1416-1425. (PMID: 28202800; PMCID: PMC5405259)
*35) Constance Agamasu and Jamil S. Saad (2017).“The Interplay Between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt”. J. Biol. Chem., 292, 251-263. (PMID: 27872186; PMCID: PMC5217684)
34) Robert L. Burton, K. Aaron Geno, Jamil S. Saad, Moon H. Nahm (2016). “Pneumococcus with the “6E” cps locus produces serotype 6B capsular polysaccharide”. J. Clin. Micro., 54, 967-971. (PMID: 26818670)
*33) Bliss J. Chang, Alexandra B. Samal, Jiri Vlach, Timothy F. Fernandez, Dewey Brook, Peter E. Prevelige Jr., and Jamil S. Saad (2016). “Identification of the Calmodulin-Binding Domains of Fas Death Receptor”. PLoS One, 11, e0146493. (PMID: 26735300; PMCID: PMC4703387)
*32) Constance Agamasu, Ruba H. Ghanam and Jamil S. Saad (2015).“Structural and biophysical characterization of the interactions between calmodulin and the pleckstrin homology domain of Akt”, J. Biol. Chem, 290, 27403-27413. (PMID: 26391397; PMCID: PMC4646410)
31) Ayala Lampel, Yaron Bram, Anat Ezer, Ronit Shaltiel-Kario, Jamil S. Saad, Eran Bacharach,and Ehud Gazit (2015). “Targeting the Early Step of Building Block Organization in Viral Capsid Assembly”. ACS. Chem. Biol., 10, 1785-1790. (PMID: 25997366).
30) Melissa B Oliver, Mark PG van der Linden, SA Küntzel, Jamil S. Saad, Moon H. Nahm (2013). “Discovery of Streptococcus pneumoniae Serogroup 6 Variants with Glycosyltransferases Synthesizing Two Differing Repeating Units”. J. Biol. Chem, 290, 26474-26475. (PMID: 26519486; PMCID: PMC4646307)
*29) Jamil S. Saad and Delphine M. Muriaux (2015). “Role of lipids in virus assembly”. Frontiers of Microbiology, 6, 410. (PMID: 25999935; PMCID: PMC4419861)
*28) Jiri Vlach and Jamil S. Saad (2015). “Structural and molecular determinants of HIV-1 Gag binding to the plasma membrane during virus assembly”. Frontiers of Microbiology, 6, 232. (PMID: 25852680; PMCID: PMC4367181)
*27) Jiri Vlach and Jamil S. Saad (2014). “HIV: a vicTIM”, Trends. Micro., 22, 603-604. (PMID: 25438615)
*26) Jiri Vlach,‡ Alexandra B. Samal,‡ and Jamil S. Saad (2014).“Solution structure of calmodulin bound to the binding domain of the HIV-1 matrix protein”, J. Biol. Chem., 289, 8697-8705. (‡ Authors contributed equally to this work) (PMID: 24500712; PMCID: PMC3961691)
25) Juan J. Calix, Allison M. Brady, Victor Du, Jamil S. Saad, and Moon H. Nahm (2014). “Spectrum of pneumococcal serotype 11A variants results from incomplete loss of capsule O-acetylation”. J. Clin. Micro. 52, 758-765. (PMID: 24352997; PMCID: PMC3957789)
24) Melissa B Oliver, Mark PG van der Linden, SA Küntzel, Jamil S. Saad, Moon H. Nahm (2013). “Discovery of Streptococcus pneumoniae Serogroup 6 Variants with Glycosyltransferases Synthesizing Two Differing Repeating Units”. J. Biol. Chem, 288, 25976-25985. (PMID: 23897812; PMCID: PMC3764802)
*23) Timothy F. Fernandez,‡ Alexandra B. Samal,‡ Gregory J. Bedwell, Yabing Chen, and Jamil S. Saad (2013). “Characterization of the interactions between the death domain of Fas receptor and calmodulin”. J. Biol. Chem., 288, 21898-21908. (‡ Authors contributed equally to this work). (PMID: 23760276; PMCID: PMC3724645)
*22) Jiri Vlach and Jamil S. Saad (2013). “Trio engagement via plasma membrane phospholipids and the myristoyl moiety governs HIV-1 matrix binding to bilayers”, Proc. Natl. Acad. Sci. USA, 110, 3525-3530. (PMID: 23401539; PMCID: PMC3587261)
– Cited on Faculty of 1000 Biology: http://f1000.com/prime/717988250
Comments: Rating 2, New Finding, Highly Recommended.
21) Juan Calix, Jamil S. Saad, Alison Brady, Moon Nahm (2012). ‘Structural Characterization of Streptococcus pneumonia serotype 9A Capsule Polysaccharide Reveals the Role of the Glycosyl 6-O-acetyltransferase wcjE’ in Serotype 9V Capsule Biosynthesis and Immunogenicity”, J. Biol. Chem, 287, 13996-14003. (PMID: 22367197; PMCID: PMC3340191)
*20) Ruba H. Ghanam, Alexandra B. Samal, Timothy F. Fernandez, Jamil S. Saad (2012). “Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly”. Invited Review in Frontiers in Microbiology, 3, 55. (PMID: 22363329; PMCID: PMC3281212)
19) Altaira D. Dearborn, Michael S. Spilman, Priyadarshan K. Damle, Jenny R. Chang, Eric B. Monroe, Jamil S. Saad, Gail E. Christie and Terje Dokland (2011) “The Staphylococcus aureus pathogenicity island 1 protein gp6 functions as an internal scaffold during capsid size determination”, J. Mol. Biol., 412, 710-722. (PMID: 21821042; PMCID: PMC3175317)
*18) Alexandra B. Samal, Ruba H. Ghanam, Timothy F. Fernandez, Eric B. Monroe and Jamil S. Saad (2011). “NMR, Biophysical and Biochemical Studies Reveal the Minimal Calmodulin-Binding Domain of the HIV-1 Matrix Protein”. J. Biol. Chem., 286, 33533-33543. (PMID: 21799007; PMCID: PMC3190893)
*17) Jamil S. Saad, Patricia A. Marzilli, Francesco P. Intini, Giovanni Natile, and Luigi G. Marzilli (2011) “Single-stranded Oligonucleotide Adducts Formed by Pt Complexes Favoring Left-handed Base Canting. Steric Effect of Flanking Residues and Relevance to DNA Adducts Formed by Pt Anticancer Drugs”. Inorg. Chem., 50, 8608-8620. (PMID: 21819051)
*16) Jamil S. Saad, Michele Benedetti, Giovanni Natile, and Luigi G. Marzilli (2011). “NMR Studies of Models Having the Pt(d(GpG)) 17-Membered Macrocyclic Ring Formed in DNA by Platinum Anticancer Drugs. Pt Complexes with Bulky Chiral Diamine Ligands”, Inorg. Chem., 50, 4559-4571. (PMID: 21510625)
*15) Ruba H. Ghanam, Timothy Fernandez, Emily Fledderman, and Jamil S. Saad (2010) “Binding of Calmodulin to the HIV-1 Matrix Protein Triggers Myristate Exposure”. J. Biol. Chem., 285, 41911-41920. (PMID: 20956522; PMCID: PMC3009918)
*14) Emily L. Fledderman, Ken Fujii, Ruba H. Ghanam, Kayoko Waki, Peter E. Prevelige, Eric O. Freed, and Jamil S. Saad (2010) “Myristate Exposure in the HIV-1 Matrix Protein is Modulated by pH”. Biochemistry, 49, 9551-9562. (PMID: 20886905; PMCID: PMC3032006)
*13) Jamil S. Saad, Michele Benedetti, Giovanni Natile, and Luigi G. Marzilli (2010). “Basic Coordination Chemistry Relevant to DNA Adducts Formed by the Cisplatin Anticancer Drug. NMR Studies on Compounds with Sterically Crowded Chiral Ligands. Inorg. Chem., 49, 5573-5583. (PMID: 20496875)
12) Kathleen G. Valentine, Ronald Peterson, Jamil S. Saad, Michael F. Summers, Xianzhong Xu, James B. Ames, and A. Joshua Wand (2010). “Reverse micelle encapsulation of membrane anchored proteins for solution NMR studies”. Structure, 18, 9-16. (PMID: 20152148; PMCID: PMC2876244)
11) Hamard-Peron, E., Juilliard, F., Jamil S. Saad, Roy, C., Roingeard, P., Michael F. Summers, Darlix, JL., Picart, C. and D. Muriaux (2010). “Targeting of MuLV Gag to the Plasma Membrane is Mediated by PI(4,5)P2/PS and a polybasic region in the Matrix. J. Virol, 84, 503-515. (PMID: 19828619; PMCID: PMC2798412)
10) Jamil S. Saad, Giovanni Natile, and Luigi G. Marzilli (2009) “Origins of the Distortions in the Base Pair Step Adjacent to Platinum Anticancer Drug-DNA Adducts. Fundamental NMR Solution Studies Utilizing Right-Handed Cross-Link Models Having 5′- and 3′-Flanking Residues”, J. Am. Chem. Soc.”, 131, 12314-12324. (PMID: 19655752)
9) Jamil S. Saad, Sherimay D. Ablan, Ruba H. Ghanam, Andrew Kim, Kalola Andrews, Kunio Nagashima, Eric O. Freed, and Michael F. Summers (2008). “Structure of the myristylated HIV-2 MA protein and the role of PI(4,5)P2 in membrane targeting”, J. Mol. Biol., 382, 434-347. (PMID: 18657545; PMCID: PMC2581411)
8) Jamil S. Saad, Andrew Kim, Ruba H. Ghanam, Amanda K. Dalton, Volker M. Vogt, Zhibin Wu, Wuyuan Lu and Michael F. Summers (2007). “Mutations that mimic phosphorylation of the HIV-1 matrix protein do not perturb the myristyl switch”,Protein Science, 16, 1793-1797. (PMID: 17656588; PMCID: PMC2203364)
7) Jamil S. Saad, Erin Loeliger, Paz Luncsford, Mellisa Liriano, Janet Tai, Andrew Kim, Jaime Miller, Anjali Joshi, Eric O. Freed and Michael F. Summers (2007). “Point Mutations in the HIV-1 Matrix Protein Turn off the Myristyl Switch”, J. Mol. Biol., 366, 574-585. (PMID: 17188710; PMCID: PMC1853300)
– Illustrated on the cover.
6) Jamil S. Saad, Jaime Miller, Janet Tai, Andrew Kim, Ruba H. Ghanam, and Michael F. Summers. (2006) “Structural Basis for Targeting HIV-1 Gag proteins to the Plasma Membrane for Virus Assembly”, Proc. Natl. Acad. Sci. USA, 103, 11364-11369. (PMID: 16840558; PMCID: PMC1544092)
– Highlighted on the cover.
– Complementary article by Eric O. Freed “HIV-1 Gag: Flipped out for PI(4,5)P2”, PNAS 103: 11101-11102 (2006)
– Cited on Faculty of 1000 Biology: http://F1000.com/prime/1046645
Comments: Rating 2, New Finding, Highly Recommended.
5) Michele Benedetti, Jamil S. Saad, Luigi G. Marzilli, Giovanni Natile (2003) Chiral Discrimination in the Formation Reaction and at Equilibrium for N,N,N’,N‘-Tetramethyl-1,2-Diaminocyclohexane-PtG2 Complexes. J. Chem. Soc., Dalton Transactions, 872-879. (https://doi.org/10.1039/B210616G)
4) Jamil S. Saad, Tomasso Scarcia, Natile, G., Luigi G. Marzilli (2002) Factors Influencing Conformer Equilibria in Models of Cisplatin-DNA Adducts As Revealed by Moderately Dynamic Me2DABPtG2 Retro Models (Me2DAB = N,N’-dimethyl-2,3-diaminobutane, and G = a Guanine Derivative), Inorg. Chem., 41, 4923-4935. (PMID: 12230397)
3) Sharon T. Sullivan, Jamil S. Saad, Francesco P. Fanizzi, Luigi G. Marzilli (2002) Dramatic 5’-Residue Effect on Conformer Distribution of Short Oligonucleotide Retro Models of the Cross-link Formed by Cisplatin With DNA. Implications for the Distorted and Cross-link Lippard Base Pair Steps Present in Cisplatin-DNA Duplex Adducts. J. Am. Chem. Soc., 124, 1558-1559. (PMID: 11853413)
2) Jamil S. Saad, Tomasso Scarcia, Kazuo Shinozuka, Giovanni Natile, Luigi G. Marzilli (2002) Modification of Second-Sphere Communication, Leading to an Unusually High Abundance of the Head-to-Head Conformer of Cisplatin Cross-Link Retro Models. Inorg. Chem., 41, 546-557. (PMID: 11825082)
1) Luigi G. Marzilli, Jamil S. Saad, Zsuzsanna Kuklenyik, Kelly A. Keating and Yinghai Xu (2001) Relation of Solution and Protein-Bound Structures of DNA Duplexes with the Major Intrastrand Cross-Link Lesions Formed on Cisplatin Binding to DNA. J. Am. Chem. Soc., 123, 2764-2770. (PMID: 11456962)
