1. Kahn-Krell A, Pretorius D, Guragain B, Lou X, Wei Y, Zhang J, Qiao A, Nakada Y, Kamp TJ, Ye L, Zhang J.  A Three-Dimensional Culture System for Generating Cardiac Spheroids Composed of Cardiomyocytes, Endothelial Cells, Smooth-Muscle Cells, and Cardiac Fibroblasts Derived from Human Induced-Pluripotent Stem Cells.  Fronters  Bioeng. Biotechnol., July 2022; Tissue Engineering and Regenerative Medicine. https://doi.org/10.3389/fbioe.2022.908848
  2. Pretorius D.  Kahn-Krell AM , LaBarge WC , Lou X ,  Zhang J .  Engineering of thick human functional myocardium via static stretching and electrical stimulation. iScience 25, 103824, March 18, 2022. https://www.cell.com/iscience/fulltext/S2589-0042(22)00094-3
  3.  Nguyen T, Wei Y, Nakada Y, Zhou Y, Zhang J. Cardiomyocyte Cell-Cycle Regulation in Neonatal Large Mammals: Single Nucleus RNA-Sequencing Data Analysis via an Artificial-Intelligence–Based Pipeline. Frontiers in Bioengineering and Biotechnology. 2022;10. https://www.frontiersin.org/articles/10.3389/fbioe.2022.914450/full
  4. Nakada Y, Zhou Y, Gong W, Zhang EY, Skie E, Nguyen T, Wei Y, Zhao M, Chen W, Sun J, Raza SN. Single Nucleus Transcriptomics: Apical Resection in Newborn Pigs Extends the Time Window of Cardiomyocyte Proliferation and Myocardial Regeneration. Circulation. 2022 Jun 7;145(23):1744-7. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.056995


  1.  Zhang J,  Bolli R, Garry DJ, Marbán E, Menasché P, Zimmermann WH, Kamp TJ,  Wu JC, Dzau VJ.  Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review.  J Am Coll Cardiol.  2021 Nov, 78 (21) 2092–2105). https://www.jacc.org/doi/pdf/ 10.1016/j.jacc.2021.09.019
  2. Chen W, Pretorius D, Zhou Y, Nakada Y, Yang Y, Zhang J. TT-10–loaded nanoparticles promote cardiomyocyte proliferation and cardiac repair in a mouse model of myocardial infarction.  JCI Insight  2021. https://insight.jci.org/articles/view/151987
  3. Kahn-Krell AM, Pretorius D,  Ou J, Fast V, Litovsky S, Joel Berry J, Liu M, Zhang J.  Bioreactor Suspension Culture: Differentiation and Production of Cardiomyocyte Spheroids From Human Induced Pluripotent Stem Cells. Frontiers in bioengineering-and-biotechnologyhttps://www.frontiersin.org/journals/bioengineering-and-biotechnology
  4. Pretorius D, Asher M. Kahn-Krell AM, Lou X, Fast VG, Berry JL, Kamp TJ, Zhang J.  Layer-by-Layer Fabrication of Large and Thick Human Cardiac Muscle Patch Constructs with Superior Electrophysiological Properties. Front. Cell Dev. Biol., 16 April 2021 | https://doi.org/10.3389/fcell.2021.670504
  5. Bian W, Chen W, Nguyen T, Zhou Y, Zhang J.  miR-199a Enhances the Cell-based Therapy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Myocardial Infarcted Hearts. Front Pharmacol. 2021; 12: 673621. Published online 2021 Jun 3. doi: 10.3389/fphar.2021.673621
  6. Zhao M, Nakada Y, Wei Y, Bian W,  Chu Y,  Borovjagin AV, Xie M, Zhu W, Nguyen T, Zhou Y, Serpooshan V, Walcott GP, Zhang J.  Cyclin D2 overexpression enhances the efficacy of human induced pluripotent stem cell-derived cardiomyocytes for myocardial recovery in a swine model of myocardial infarction.  Circulation May 2021 https://doi.org/10.1161/CIRCULATIONAHA.120.049497
  7. Pretorius D, Kahn-Krell AM, LaBarge WC, Lou X, Kannappan R, Pollard AE, Fast VG, Berry JL, Eberhardt AW, Zhang J .  Fabrication and characterization of a thick, viable bi-layered stem cell-derived surrogate for future myocardial tissue regeneration.  Biomed Mater. 2020 Oct 14. doi: 10.1088/1748-605X/abc107
  8. Bishop S, Zhou Y, Nakada Y, Zhang J.  Changes in Cardiomyocyte Cell Cycle and Hypertrophic Growth During Fetal to Adult in Mammals.   JAHA.  2021, Jan 05. https://www.ahajournals.org/doi/10.1161/JAHA.120.017839


  1. Gao L, Wang L, Wei Y, Krishnamurthy P, Walcott GP,  Menasché P, Zhang J.   Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine.  Science Translational Medicine 16 Sep 2020:Vol. 12, Issue 561, eaay1318
    DOI: 10.1126/scitranslmed.aay1318
  2. Zhao M, Zhang E, Wei Y, Zhou Y, Walcott GP, Zhang J  Apical Resection Prolongs the Cell Cycle Activity and Promotes Myocardial Regeneration after LV Injury in Neonatal Pig. Circulation 2020; 142:913-916. https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.119.044619
  3. Fan C, Oduk Y, Zhao M, Lou X, Tang Y, Pretorius D, Valarmathi MT, Walcott GP, Yang J, Menasche P, Krishnamurthy P, Zhu W, Zhang J .  Myocardial protection by nanomaterials formulated with CHIR99021 and FGF1.  JCI Insight 2020 Jun 18;5(12):e132796. PMID:  32453715. PMCID: PMC7406256.
  4. Zhou Y, Zhang J.  Single-cell Transcriptomics: New Insights in Heart Research.  Circulation 2020 May 26; 141 (21), 1720-1723. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.046043#d1e295
  5. Lou X, Zhao M, Fan C, Fast VG, Valarmathi MT, Zhu W, Zhang J. N-cadherin overexpression enhances the reparative potency of human-induced pluripotent stem cell-derived cardiac myocytes in infarcted mouse hearts. Cardiovasc Res. 2020 Mar 1;116(3):671-685. doi: 10.1093/cvr/cvz179. PubMed PMID: 31350544; PubMed Central PMCID: PMC8204485.
  6. Fan C, Tang Y, Zhao M,  Lou X, Pretorius D, Menasche P, Wuqiang Zhu, Zhang J.  CHIR99021 and Fibroblast Growth Factor 1 Enhance the Regenerative Potency of Human Cardiac Muscle Patch after Myocardial Infarction in Mice. J Mol Cell Cardiol. 2020  141 · March DOI: 10.1016/j.yjmcc.2020.03.003


  1. Zhao M, Tang Y, Zhou Y, Zhang J. Deciphering Role of Wnt Signalling in Cardiac Mesoderm and Cardiomyocyte Differentiation from Human iPSCs: Four-dimensional control of Wnt pathway for hiPSC-CMs differentiation.  Scientific Report,  2019 Dec 18;9(1):19389. doi: 10.1038/s41598-019-55620-x. PubMed PMID: 31852937; PubMed Central PMCID: PMC6920374
  2. LaBarge W, Morales A, Pretorius D, Kahn-Krell AM, Kannappan R, Zhang J. Scaffold-Free Bioprinter Utilizing Layer-By-Layer Printing of Cellular Spheroids. Micromachines (Basel). 2019 Aug 29;10(9). PMID: 31470604
  3. Kannappan R, Turner JF, Miller JM, Fan C, Rushdi A, Rajasekaran NS, Zhang J. Functionally Competent DNA Damage-Free iPS-Derived Cardiomyocytes for Myocardial Repair. Circulation. 2019 Aug 6;140(6):520-522. Epub 2019 Aug 5. PMID: 31381423
  4. Lou X, Zhao M, Fan C, Fast VG, Valarmathi MT, Zhu W, Zhang J. N-cadherin Overexpression Enhances the Reparative Potency of Human iPSC-Derived Cardiac Myocytes in Infarcted Mouse Hearts. Cardiovascular Research. 2019 July 26. pii:cvz179. PMID: 31350544
  5. Zhao M, Tang Y, Ernst PJ, Kahn-Krell A, Fan C, Pretorius D, Zhu H, Lou X, Zhou L, Zhang J, Zhu W. Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity. J Vis Exp. 2019 July 10;(149). PMID: 31355804
  6. LaBarge W, Mattapally S, Kannappan R, Fast VG, Pretorius D, Berry JL, Zhang J. Maturation of Three-dimensional, hiPSC-derived Cardiomyocyte Spheroids utilizing Cyclic Uniaxial Stretch and Electrical Stimulation. PLoS One. 2019 July 5;14(7):e0219442. eCollection. PMID: 31276558; PMCID: PMC6611624
  7. Zhao M, Fan C, Ernst PJ, Tang Y, Zhu H, Mattapally S, Oduk Y, Borovjagin AV, Zhou L, Zhang J, Zhu W. Y-27632 Preconditioning Enhances Transplantation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Myocardial Infarction Mice. Cardiovascular Research. 2019 Feb 1;115(2):343-356. Epub 2018 Aug 13. PMID: 30107391; PMCID: PMC6341224
  8. Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circulation Research. 2019 Jan 3;124(1):161-169. PMID: 30605412; PMCID: PMC6350935


  1. Zhu W, Zhang E, Zhao M, Chong Z, Fan C, Tang Y, Hunter JD, Borovjagin AV, Walcott GP, Chen JY, Qin G, Zhang J. Regenerative Potential of Neonatal Porcine Hearts. Circulation. 2018 Dec 11;138(24):2809-2816. Epub 2018 July 20. PMID: 30030418; PMCID: PMC6301098
  2. Gao L, Yang L, Wang L, Geng Z, Wei Y, Gourley G, Zhang J. Relationships between the Efficacy of Cardiac Cell Therapy and the Inhibition of Differentiation of Human iPSC Derived Non-Myocyte Cardiac Cells into Myofibroblast-Like Cells. Circulation Research. 2018 Dec 7;123(12):1313-1325. Epub 2018 Oct 19. PMID: 30566050; PMCID: PMC6309999
  3. Mattapally S, Pawlik KM, Fast VG, Martinez EZ, Lund F, Randall T, Townes TM, Zhang J. Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. Journal of the American Heart Association. 2018 Dec 4;7(23):e010239. PMID: 30488760; PMCID: PMC6405542
  4. Kannappan R, Mattapally S, Wagle PA, Zhang J. Transactivation Domain of p53 Regulates DNA Repair and Integrity in Human iPS Cells. Am J Physiol Heart Circ Physiol. 2018 Sept 1;315(3):H512-H521. Epub 2018 May 18. PMID: 29775409; PMCID: PMC6172637
  5. Mattapally S, Zhu W, Fast VG, Worley C, Gao L, Kannappan R, Borovjagin A, Zhang J. Spheroids of Cardiomyocytes Derived from Human, Cardiac-Lineage, Induced-Pluripotent Stem Cells Improve Recovery from Myocardial Injury in Mice. Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H327-H339. Epub 2018 Apr 6. PMID: 29631371; PMCID: PMC6139622
  6. Gao L, Gregorich ZR, Zhu W, Mattapally S, Oduk Y, Lou X, Kannappan R, Borovjagin AV, Walcott GP, Pollard AE, Fast VG, Hu X, Lloyd SG, Ge Y, Zhang J. Large Cardiac Muscle Patches Engineered from Human Induced-Pluripotent Stem-Cell-Derived Cardiac Cells Improve Recovery from Myocardial Infarction in Swine. Circulation. 2018 April 17;137(16):1712-1730. Epub 2017 Dec 12. PMID: 29233823; PMCID: PMC5903991
  7. Oduk Y, Zhu W, Kannappan R, Zhao M, Borovjagin AV, Oparil S, Zhang J. VEGF Nanoparticles Repair Heart after Myocardial Infarction. Am J Physiol Heart Circ Physiol. 2018 Feb 1:314(2):H278-H284. Epub 2017 Nov 3. PMID: 29101176; PMCID: PMC5867653
  8. Zhu W, Zhao M, Mattapally S, Chen S, Zhang J. CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle. Circulation Research. 2018 Jan 5;122(1):88-96. Epub 2017 Oct 10. PMID: 29018036; PMCID: PMC5756126

More publications in Zhang lab can be found here!