Our research program is dedicated to defining the molecular mechanisms that underlie cardiovascular biology and contribute to the recovery from cardiovascular disease, and to translating the results from these basic science investigations to clinical applications. In particular, we are committed to improving cardiovascular tissue protection, repair, and regeneration during ischemic injuries.
A portion of our research focuses on the transcriptional networks and genetic pathways that control the growth and function of blood vessels; our lab for the first time revealed the roles of the E2F oncogenes in the ischemic angiogenesis and blood pressure regulation. Another major focus is to improve the reparative capacity of endogenous stem cells, including bone marrow and cardiac stem cells, for the treatment of ischemic heart disease; our work has contributed to the advancement of the field by identifying novel molecular interactions between stem cells and their microenvironment and by establishing the significance of specific mobilization of stem cells in the ischemic tissue repair. More recently, we have revealed a pivotal role of oxidative metabolism in the differentiation of endothelial progenitor cells. Additionally, our lab has identified a unique population of cardiac stem cells in the rodent heart and are systemically evaluating their regenerative capacity. Other ongoing research includes epigenetic mechanisms of cardiac differentiation of embryonic and induced-pluripotent stem (ES and iPS) cells, development of peptide-based nanoparticles for enhancing the therapeutic benefit of human progenitor cells, and novel signaling pathways linking adipose and liver metabolisms to cardiovascular function and disease.
Our lab is conveniently located at a newly renovated space on the UAB main campus, equipped with the state-of-the-art instrument and infrastructure, and supported by highly collaborative UAB centers and core facilities. Importantly, our research program provides comprehensive training for pre- and post-doctoral fellows interested in molecular biology, stem cell biology, genomics, cardiovascular physiology and pathology. Over the years, our lab has established an outstanding track record of success in training young scientists.
I welcome you to visit our lab and meet with this group of outstanding scientists committed to improving cardiovascular health and quality of life.
Gangjian (GQ) Qin, MD
Professor of Medicine and Engineering
Director, Molecular Cardiology Program
Department of Biomedical Engineering
School of Medicine, School of Engineering