This spring, Arlet Hernandez, soon to be Dr. Hernandez, had two articles accepted. In the first, published in Chemico-Biological Interactions in May (https://pubmed.ncbi.nlm.nih.gov/38582340/), she describes the non-cytotoxic exposure effects of dihydroxyacetone (DHA) on rat cardiomyocytes. This work established that DHA exposure induced mitochondrial reprogramming with dose-specific effects between 1 and 2 mM DHA.

In the second recently accepted article, which will soon be published in Toxicological Sciences, the lab has comprehensively characterized the genotoxic effects of DHA. This work, for the first time, demonstrated DHA has cell-specific genotoxicity and induced chromosomal aberrations. The identification of DHA’s induction of chromosomal instability may have health implications for exposure effects, which the lab will continue to investigate.

In a recently accepted publication by graduate student Arlet Hernandez, we describe the mitochondrial and metabolic changes induced by the three carbon sugar dihydroxyacetone in a liver cell models. Check out the work when it is published on December 6th, 2022.