Dr. Dudeja’s laboratory focuses on deciphering the biology of tumor microenvironment in pancreatic cancer and interaction of gut microbiome with anti-cancer immune response. Elucidation of the mechanism and determinants of tumor recurrence is another key area studied in his laboratory. 

Select Publications:

Prognostic Impact of Tumor Size on Pancreatic Neuroendocrine Tumor Recurrence May Have Racial Variance. Zheng-Pywell R, Fang A, AlKashash A, Awad S, Reddy S, Vickers S, Heslin M, Dudeja V, Chen H, Rose JB.Pancreas. 2021 Mar 1;50(3):347-352. doi: 10.1097/MPA.0000000000001776.PMID: 33835965

The Role of Perioperative Chemotherapy in the Management of Colloid Carcinoma of the Pancreas.Picado O, Dosch AR, Garcia-Buitrago MT, Yakoub D, Dudeja V, Rodgers SE.Pancreas. 2021 Mar 1;50(3):306-312. doi: 10.1097/MPA.0000000000001787.PMID: 33835960

New Insights Into the Cancer-Microbiome-Immune Axis: Decrypting a Decade of Discoveries.Jain T, Sharma P, Are AC, Vickers SM, Dudeja V.Front Immunol. 2021 Feb 23;12:622064. doi: 10.3389/fimmu.2021.622064. eCollection 2021.PMID: 33708214 Free PMC article. Review.

Neoadjuvant therapy alters the biliary microbiome in PDAC.Jain T, Dudeja V.Am J Surg. 2021 Jan 1:S0002-9610(20)30828-X. doi: 10.1016/j.amjsurg.2020.12.050. Online ahead of print.PMID: 33431167 No abstract available.

The war against pancreatic cancer in 2020 – advances on all fronts.Jain T, Dudeja V.Nat Rev Gastroenterol Hepatol. 2021 Feb;18(2):99-100. doi: 10.1038/s41575-020-00410-4.PMID: 33414515 Review. No abstract available.

Gamma Secretase Inhibitors in Cancer: A Current Perspective on Clinical Performance.McCaw TR, Inga E, Chen H, Jaskula-Sztul R, Dudeja V, Bibb JA, Ren B, Rose JB.Oncologist. 2021 Apr;26(4):e608-e621. doi: 10.1002/onco.13627. Epub 2021 Jan 2.PMID: 33284507 Free PMC article. Review.

Impact of the coronavirus disease 2019 pandemic on surgical research and lessons for the future.Keswani SG, Parikh UM, Gosain A, Ghaferi AA, Thomas JS, Dudeja V, Kim ES, Zuckerbraun BS, Goldstein AM.Surgery. 2021 Feb;169(2):257-263. doi: 10.1016/j.surg.2020.09.012. Epub 2020 Sep 19.PMID: 33077199 Free PMC article.

Modulation of macrophage polarity for treatment of acute pancreatitis: Are we there yet?Sahay P, Bava EP, Iyer S, Dudeja V.EBioMedicine. 2020 Oct;60:103002. doi: 10.1016/j.ebiom.2020.103002. Epub 2020 Sep 23.PMID: 32979834 Free PMC article. No abstract available.

An Immunocompetent Model of Pancreatic Cancer Resection and Recurrence.
Giri B, Ferrantella A, Sharma P, Jain T, Jacob HKC, Modi S, Kurtom S, Roy P, Sethi V, Banerjee S, Merchant N, Ramakrishnan S, Saluja A, Dudeja V.J Gastrointest Surg. 2020 Jun 15:10.1007/s11605-020-04681-9. doi: 10.1007/s11605-020-04681-9. Online ahead of print.PMID: 32542554

Symphony in chaos: Immune orchestra during pancreatic cancer progression.Sharma P, Jain T, Sethi V, Dudeja V.EBioMedicine. 2020 Jun;56:102787. doi: 10.1016/j.ebiom.2020.102787. Epub 2020 May 23.PMID: 32454409 Free PMC article. No abstract available.

The role of total pancreatectomy with islet autotransplantation in the treatment of chronic pancreatitis: A report from the International Consensus Guidelines in chronic pancreatitis.Abu-El-Haija M, Anazawa T, Beilman GJ, Besselink MG, Del Chiaro M, Demir IE, Dennison AR, Dudeja V, Freeman ML, Friess H, Hackert T, Kleeff J, Laukkarinen J, Levy MF, Nathan JD, Werner J, Windsor JA, Neoptolemos JP, Sheel ARG, Shimosegawa T, Whitcomb DC, Bellin MD.Pancreatology. 2020 Jun;20(4):762-771. doi: 10.1016/j.pan.2020.04.005. Epub 2020 Apr 14.PMID: 32327370

Vaccination against Nonmutated Neoantigens Induced in Recurrent and Future Tumors.Garrido G, Schrand B, Levay A, Rabasa A, Ferrantella A, Da Silva DM, D’Eramo F, Marijt KA, Zhang Z, Kwon D, Kortylewski M, Kast WM, Dudeja V, van Hall T, Gilboa E.Cancer Immunol Res. 2020 Jul;8(7):856-868. doi: 10.1158/2326-6066.CIR-20-0020. Epub 2020 Apr 15.PMID: 32295785

inimally Invasive Surgery is Associated with an Increased Risk of Postoperative Venous Thromboembolism After Distal Pancreatectomy.Willobee BA, Dosch AR, Allen CJ, Macedo FI, Bartholomew TS, Picado O, Gaidarski AA, Dudeja V, Yakoub D, Merchant NB.Ann Surg Oncol. 2020 Jul;27(7):2498-2505. doi: 10.1245/s10434-019-08166-1. Epub 2020 Jan 9.PMID: 31919713