Timing of Diet and Kidney Pathophysiology in Diet-Induced Obesity
National Institute of Diabetes and Digestive and Kidney Diseases, R01 DK134562 (D.Pollock, J.Pollock, Co-P.I.s)
The central hypothesis states that time restricted feeding ameliorates kidney fibrosis driven by diet-induced obesity through reinstating the kidney molecular clock and mitochondrial function as well as reducing endothelial activation and kidney pro-inflammatory T cell infiltration.
Early Life Stress Induced Mechanisms of Cardiovascular Disease Risk and Resilience
National Heart Lung & Blood Institute, P01 HL158500 (J. Pollock, P.I., D. Pollock, Project 2 Leader and Cardiovascular Phenotyping Core Leader)
The overall goal of the program project grant is to define mechanisms by which early life stress (ELS) leads to cardiovascular disease (CVD) risk and inform strategies for prevention and effective treatment of CVD consequences in individuals exposed to ELS. Project 2 focuses on circadian and brain-related mechanisms responsible for hypertension hypersensitivity in rat models of ELS.
Timing of sodium intake and nocturnal sodium excretion and blood pressure in obese African Americans
National Heart Lung & Blood Institute, R01 HL144716 (D.Pollock, O.Gutierrez, co-P.I.’s)
The first aim is to test the hypothesis that limiting high salt intake prior to sleep increases day-night differences in blood pressure, improves timing of urinary sodium excretion, and improves metabolic risk factors. The second aim tests the hypothesis that limiting high salt intake prior to sleep preferentially improves rhythmicity in peripheral vs. central circadian clock factors linked to renal sodium handling.
APOL1 Gene Variants and ET-1 as Predictors of Sickle Nephropathy
UAB AMC21 Multi-PI Award (J. Pollock, D.Pollock, J.Lebensburger, M.Kasztan, Co-PIs)
The goal of this project is to gather sufficient preliminary data to apply for a multi-investigator R01 to determine whether the combination of elevated ET-1 and APOL1 mutations result in early progression to end stage kidney disease as well as provide mechanistic insight with both basic and clinical studies.
Molecular Mechanisms of Early Life Stress and Risk of Inflammatory Bowel Disease
Crones & Colitis Foundation (J. Pollock, P.I., D.Pollock, co-investigator)
This project aims to exploit key pathways for primary prevention or intervention strategies and signatures of childhood stress that may impact IBD risk and/or disease course.
Deep South KUH Premier Research and Interdisciplinary Mentored Education (PRIME)
National Institute of Diabetes and Digestive and Kidney Diseases, U2C DK133422 (D.Pollock, TL1 Training Core Director)
The overall mission of the TL1 Training Core is to provide training in interdisciplinary and translational research that ensures pre- and post-doctoral trainees will learn the skills and knowledge to successfully transition to the next steps of their careers in KUH research. The unifying vision is that the TL1 core works synergistically with the Professional Development and Network Cores and other training programs in our institutions to provide early investigators (pre-doctoral and post-doctoral trainees) with the requisite skill set to efficiently expand research in kidney, and non-malignant urology and hematology diseases.
PENDING
A Brain-Adrenal-Kidney Axis for Circadian Control of Fluid-Electrolyte Homeostasis
National Heart Lung & Blood Institute, R01 (D.Pollock, K.Gamble, co-P.I.’s)
Our overall goal is to test the hypothesis that the functional outputs of the SCN drive the peripheral responses to high salt intake via the ET-1/ETB signaling pathway.
