Contreras Chromosome Biology
Laboratory.
Our laboratory is investigating the function of repetitive areas of the human genome. We have a special interest in centromere and telomere genomics. Destabilization of centromere and telomere function results in chromosome instability (CIN), hallmarks of fibrosis and cancer. We are investigating the structure and evolution of centromere sequences, the epigenetic interactions of chromatin factors that modulate centromere function, and the role these elements play in CIN, fibrosis, and cancer.
Job opportunities
Researcher V
The University of Alabama at Birmingham (UAB) is seeking a highly motivated Researcher II to join our multi-disciplinary team in the Contreras-Galindo Laboratory. This role will perform an important task of the research group that investigates the function of repetitive areas of the human genome. The group has a special interest in molecular biology, cytogenetics and genomics of centromeres and telomeres. Special preference will be experience in molecular biology and microscopy. Our laboratory is investigating the structure and evolution of centromere sequences, the epigenetic interactions of chromatin factors that modulate centromere function on centromere sequences, and the role these elements play in chromosome segregation and genome instability in non-disjunction disorders, cancers, and fibrosis. Please email contrerr@uab.edu your CV and 2 references if interested.
Postdoctoral Fellow Stem Cell Biology and Fibrosis
We are seeking a highly motivated Postdoctoral Fellow to join our multi-disciplinary team in the Laboratory of Chromosome biology. The group has a special interest in genomics of centromeres and telomeres and the function of these structures in fibrosis and cancer development. Special preference will be experience with culture, reprogramming and differentiation of stem cells and development of organoids. Also, special preference will be given to candidates that generate mouse fibrosis models.
Our lab is funded by NIH and UAB grants.
The candidates need a PhD in Cell and Molecular Biology, Genetics, Cancer Biology or related fields and will continue their training in research. Ideal skills are mammalian cell culture, stem cell culture, generation of iPSc, cell reprogramming, confocal microscopy, molecular biology (PCR, RT-PCR, qPCR, cloning, transfection, genome editing, western blotting), ELISA, colorimetric assays, RNA-seq, DNA-seq, ChIP-Seq.
Duties/Responsibilities: As a member of our group, the candidate would be expected to be a leader, both intellectually and in the lab. The candidate would be expected to work on multiple aspects of one or more projects at any one time. This will include, but is not limited to, experimental design, implementation, and data collection as well as the analysis, dissemination of research data, manuscript publication, and grant writing. The individual would be expected to work independently but also to frequently collaborate with other lab members as well as scientists at other institutions. As an integral part of our research team, the candidate would be expected to help us to always maintain a safe and professional work environment, and to actively participate in regular group meetings. Please email contrerr@uab.edu your CV and 2 references if interested.
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