Contreras Chromosome Biology
Laboratory.
Our laboratory is investigating the function of repetitive areas of the human genome. We have a special interest in centromere and telomere genomics. Destabilization of centromere and telomere function results in chromosome instability (CIN), hallmarks of fibrosis and cancer. We are investigating the structure and evolution of centromere sequences, the epigenetic interactions of chromatin factors that modulate centromere function, and the role these elements play in CIN, fibrosis, and cancer.
