23BR – Cancer Stem Cells and Tumor Vascular Microenvironment

Status: Available
Faculty Name: bin-ren-3
Primary Faculty Appointment: UAB
UAB/HA Department: Surgery
Campus Address: 1824 6TH Ave South Wallace Tumor Institute WTI630C2 (O) & WTI620E (L) Birmingham, AL35294
Telephone Number: (205) 996-2582
Email: bren@uab.edu or Click to Send E-Mail
For how many summers have you served as a preceptor: 2
CCC Research Area: Cancer Biology & Immunology
Number of hours per week that the preceptor will personally supervise or work with the intern: 2
Other faculty, staff, or graduate students who may help to supervise the intern:
1. 2 Other faculty, staff, or graduate students who may help to supervise the intern
2. Dr.Abdellah Akil, Dr Ana Karen
Title of Project: 23BR – Cancer Stem Cells and Tumor Vascular Microenvironment
Project Description:

: In various solid cancers, endothelial cells (ECs) promote self-renewal of tumor-initiating cells (TICs) or cancer stem cells (CSCs) by direct cell–cell contact or activation of Notch signaling. Microvascular remodeling and arterioles are critical to the progression of breast, lung and skin cancers, for which the differentiation of microvascular ECs (MVECs) is essential in the tumor microenvironment (TME). MVEC differentiation into arteriolar EC may create a unique vascular niche to enhance the self-renewal capacity of CSCs due to an increase in arterial markers, ephrin B2 and delta-like ligand 4 (DLL4, a key ligand in the Notch pathway). This proposal challenges current antiangiogenic therapy against solid tissue cancers by elucidating mechanisms of arteriolar differentiation of tumor-associated (TA) MVECs or TAECs and targeting both arteriolar remodeling and CSCs to control metastasis of estrogen receptor-positive breast cancer (ER+BC).

Project Status: Already up and running
Location of Project: Birmingham, AL (UAB)
Proposed Start Date: May 3, 2021
Proposed End Date: August 27, 2021
Expected work schedule for intern: Flexible, intern can largely set his or her own schedule (as for students who are instructed how to proceed and are permitted to work independently with weekly guidance) and should contribute full-time effort.
Number of days that the student will be expected to come physically to UAB:
More than 1 day per week (prior to start of the internship, gain appropriate waivers and approvals for the student to be on site)
Category of Project: Laboratory Research
Cancer topic: Breast, Pancreas
Does this project involve human subjects: No
Does this project involve animal subjects: Yes

Learn relevant knowledge and techniques


Presentation in the lab meetings


Write and contribute abstracts to academic meetings.

Preceptor will provide intern with access to the following: Office or desk space, Computer and printer, Laboratory work bench space, Supplies needed to complete project, Equipment needed to complete project
Likelihood that intern will be included as an author on one or more publications related to this summer research project: Very likely
Areas in which the ideal candidates will have experience: Biochemistry, Cell Biology, Grant Proposal Preparation, Literature Review Skills, Molecular Biology, Pathology, Pharmacology, NONE OF THE ABOVE (just the willingness to learn)