13NY – TLR4 polymorphisms and predisposition for skin cancer development

Status: Available
Faculty Name: nabiha-yusuf-2
Primary Faculty Appointment: UAB
UAB/HA Department: Dermatology
Campus Address: VH566A
Telephone Number: (205) 934-7432
Email: nabihayusuf@uabmc.edu or Click to Send E-Mail
For how many summers have you served as a preceptor: 3 or more
CCC Research Area: Cancer Control & Population Science
Number of hours per week that the preceptor will personally supervise or work with the intern: 10
Other faculty, staff, or graduate students who may help to supervise the intern:
1. M. Asif Sherwani
Title of Project: 13NY – TLR4 polymorphisms and predisposition for skin cancer development
Project Description:

Toll-like receptors (TLRs) play a key role in the innate immune system. Toll-like receptor-4 (TLR4) in particular, appears to play a role in susceptibility to cancer. Of 44 identified SNPs (small nucleotide polymorphisms) in TLR4, the most common is an A–G substitution at nucleotide position +896, downstream of the cDNA start codon, a missense mutation which leads to an amino acid substitution Asp299Gly in the third exon of the TLR4 gene. Pre-clinical studies from our laboratory have shown an association of TLR4 with ultraviolet radiation induced skin cancer. Hence, in this study we will assess the pattern of TLR4 polymorphisms and susceptibility to skin cancer.

Project Status: Already up and running
Location of Project: Birmingham, AL (UAB)
Proposed Start Date: May 3, 2021
Proposed End Date: August 27, 2021
Expected work schedule for intern: Flexible, intern can largely set his or her own schedule (as for students who are instructed how to proceed and are permitted to work independently with weekly guidance) and should contribute full-time effort.
Number of days that the student will be expected to come physically to UAB:
1 day or a few days as needed
Category of Project: Analytical/Statistical Research
Cancer topic: Skin
Does this project involve human subjects: Yes
Does this project involve animal subjects: No

Analyze data


Review literature


Write manuscript

Preceptor will provide intern with access to the following: Office or desk space, Computer and printer
Likelihood that intern will be included as an author on one or more publications related to this summer research project: Very likely
Areas in which the ideal candidates will have experience: Literature Review Skills, Manuscript Preparation for Submission to a Journal, SAS Programming, Statistical Genetics, Statistics and Data Management, basic knowledge