Bhatnagar, Sushant, Ph.D.
Associate Professor of Medicine, Division of Endocrinology, Diabetes, and Metabolism
Member, Diabetes Research Center
Member, Nutritional and Obesity Research Center
Associate Scientist, Center for Exercise and Medicine
Scientist, Center for Clinical and Translational Science
Research Areas
Insulin secretion, SNARE biology, beta-cell biology, GPCR signaling, Type 2 diabetes, Obesity, Thermogenesis, Bioinformatics
Education
Graduate School
Ph.D., West Virginia University, Morgantown
Postdoctoral Fellowship
University of Wisconsin, Madison
Research Interests
The pancreatic islet β-cell function is critical for maintaining whole-body glucose homeostasis. Due to its central role in physiology, reduced β-cell function leads to the development of Type 2 diabetes. In the Bhatnagar lab, we are focused on elucidating mechanisms underlying insulin secretion and devising novel approaches for improving insulin secretion and, consequently, β-cell function for the treatment and prevention of Type 2 diabetes.
Nutrients and hormones activate cell signaling transduction pathways to modulate insulin secretion in β-cells. However, how cell signaling pathways control the fusion of insulin granules to the plasma membrane for insulin secretion is not well known. Currently, we are working to understand a) protein complexes that modulate the fusion of insulin granules, b) autocrine regulation of insulin secretion, c) GPCR-signaling mediated regulation of insulin secretion and β-cell mass, and d) crosstalk between distinct islet cell types. Understanding all these is vital to comprehensively understanding the complex biology governing β-cell function and developing new therapeutic interventions to treat Type 2 diabetes.
Teaching/Mentoring Philosophy
As a mentor, my primary role is to guide and support students through their learning journey, whether in the classroom or lab. I strive to create an empowering environment that fosters a deep understanding of science and its practical applications in everyday life, environmental issues, and health challenges.
To achieve these teaching goals, I prioritize active engagement, encouraging students to participate in discussions about the topics we cover. This interactive approach not only sharpens their critical thinking skills but also helps them clarify their understanding. The questions they raise offer valuable insights into the effectiveness of my teaching, allowing me to adjust the clarity, pace, and content of my lectures or conversations to maintain interest and ensure that the material is effectively communicated.
Particularly in the lab, I emphasize collaborative learning in small-group settings, where students can freely exchange ideas, formulate hypotheses, and conduct experiments. This hands-on approach fosters a sense of discovery that goes beyond mere rote learning. I often initiate conversations by asking students to share their daily activities, creating a relaxed atmosphere that naturally leads to discussions on relevant research topics. Moreover, I ensure that students remain mindful of the broader context, emphasizing the intricate relationships between the environment and human impact. Recognizing each student’s unique learning needs, I continuously adapt and evolve my teaching methods, viewing teaching as a dynamic, reciprocal process. I, too, learn and grow alongside my students/trainees. In the lab, I encourage everyone to take on teaching or mentoring roles, believing that “teaching is the best way to learn.” This approach has consistently proven beneficial, enriching the learning experience for all involved.
