Renal Sensory Nerve Contribution to Hypertension

National Heart Lung & Blood Institute, K01 HL159047 (B. Becker)

The overall goal of this project is to define the role that the sensory nerves of the kidneys play in increasing sympathetic nervous system activity and thereby increasing cardiovascular disease. The project utilizes cutting-edge techniques of neuronal labeling, imaging, and in-vivo recording.

CHORUS Study: Circadian Rhythms and Normal Pressure Hydrocephalus

Integrative Center for Aging Research Center, Intramural Pilot Program (B. Becker, H. Marshall Co-PIs)

The goal of this pilot project is to gain preliminary data supporting the hypothesis of altered circadian rhythms as a mechanism promoting increased brain water (hydrocephalus). The Bmal1 knockout rat is proposed as a model for normal pressure hydrocephalus, and the project utilizes behavioral studies, central administration of endothelin antagonists, and measuring of sleep in NPH patients before and after treatment.