Publications

Peer-reviewed (*corresponding author)

  1. Thalacker-Mercer AE, Fleet JC, Craig BA, Carnell NS, Campbell WW. Inadequate protein intake affects skeletal muscle transcript profiles in older humans. Am J Clin Nutr 2007 May; 85(5):1344-52. PMCID:PMC2447912          
  2. Thalacker-Mercer AE, Johnson CA, Yarasheski KE, Carnell NS, Campbell WW. Nutrient ingestion, protein intake, and sex, but not age affect albumin synthesis rate in humans. J Nutr 2007 July; 137 (7): 1734-40. PMCID:PMC3885871
  3. Stull AJ, Iglay HB, Apolzan JW, Thalacker-Mercer AE, and Campbell WW. Liquid and solid meal replacement products differentially affect postprandial appetite and food intake in older humans. J Am Diet Assoc. 2008 Jul;108(7):1226-30. PMCID:PMC2556245
  4. Thalacker-Mercer AE, Petrella JK, Bamman MM. Does habitual dietary intake influence myofiber hypertrophy in response to resistance training? A cluster analysis. Appl Physiol Nutr Metab. 2009 Aug;34(4):632-9. PMCID:PMC3188961
  5. Thalacker-Mercer AE, Dell’Italia LJ, CuiX, Cross JM, and Bamman MM. Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loading. Physiological Genomics. Physiol Genomics; 2010 Feb 4;40(3):141-9. PMCID:PMC2825766
  6. Thalacker-Mercer AE, Fleet JC, Craig BA, and Campbell WW. The skeletal muscle transcript profile reflects accommodative responses to inadequate protein intake in younger and older males. J Nutr Biochem. 2010 Nov;21(11):1076-82. PMCID: PMC2891367
  7. Kwak HB, Thalacker-Mercer AE, Anderson EJ, Lin CT, Kane DA, Lee NS, Cortright RN, Bamman MM, and Neufer PD. Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes. Free Radic Biol Med. 2011 Oct 25. PMCID: PMC3313473
  8. Thalacker-Mercer A, Stec M, Cui X, Cross J, WindhamS, and Bamman M. Cluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy. Physiol Genomics. 2013 Jun 17;45(12):499-507. PMCID: PMC3680779
  9. Merritt E, Thalacker-Mercer A, Cross J, Windham S, Thomas S, Bamman M. Increased expression of atrogenes and TWEAK family members after severe burn injury in non-burned human skeletal muscle. J Burn Care Res. 2013 Sep-Oct;34(5):e297-304. PMCID: PMC3770758
  10. Merritt E, Stec M, Thalacker-Mercer A, Windham S, Cross J, Shelley D, Tuggle S, Kosek D, Kim J, and Bamman, M. Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans. J Appl Physiol (1985). 2013 Sep;115(6):937-48. PMCID: PMC3764621
  11. Day K, Waite L, Thalacker-Mercer A, West A, Bamman M, Brooks J, Myers R, and Absher D. Differential DNA methylation with age is a result of both common and tissue-specific effects that are influenced by CpG landscape. Genome Biol. 2013 Sep;14(9):R102. PMCID: PMC4053985.
  12. Thalacker-Mercer A, Ingram K, Guo F, Newgard C, and Garvey W. Amino Acids and Insulin Sensitivity in Humans: positive correlation between glycine and clamp measures of insulin sensitivity, and negative correlation with leucine/isoleucine, are differentially affected by BMI, RQ, and diabetes. Diabetes. 2014 Feb;63(2):791-800. PMCID: PMC3900549.
  13. Mentch SJ, Mehrmohamadi M, Huang L, Liu X, Gupta D, Mattocks D, Gómez Padilla P, Ables G, Bamman MM, Thalacker-Mercer AE, Nichenametla SN, Locasale JW. Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. Cell Metab. 2015 Sep 22. pii: S1550-4131(15)00457-X.
  14. Taesuwan S, Cho C, Malysheva O, Bender E, Yan J, Thalacker-Mercer A, Caudill M. The metabolic fate of isotopically labeled trimethylamine-N-oxide (TMAO) in humans. J Nutr Biochem. 2017 Jul;45:77-82.
  15. Stec M, Thalacker-Mercer A, Mayhew D, Kelly N, Tuggle S, Merritt E, Brown C, Vaughn K, Windham S, Dell’Italia L, and Bamman M. Randomized, Four-Arm, Dose-Response Clinical Trial to Optimize Resistance Exercise Training for Older Adults with Age-Related Muscle Atrophy. Exp Gerontol. 2017 Dec 1;99:98-109.
  16. Roberts B, Lavin K, Many G, Thalacker-Mercer A, Merritt E, Bickel CS, Mayhew D, Tuggle SC, Cross J, Kosek D, Petrella J, Brow C, Hunter G, Windham S, Allman R, and Bamman M. Human Neuromuscular Aging: Sex Differences Revealed at the Myocellular Level. Exp Gerontol. 2018 Jun;106:116-124
  17. Riddle E, Bender E and *Thalacker-Mercer A. Transcript profile distinguishes variability in human myogenic progenitor cell expansion capacity.Physiol Genomics. 2018 Oct 1;50(10):817-827
  18. Riddle E, Bender E and *Thalacker-Mercer A. Expansion capacity of human myogenic progenitor cells differs by age, sex, and metabolic fuel preference. Am J Physiol Cell Physiol. 18 OCT 2018
  19. Gheller B, Blum J, Merritt E, Cummings B, and *Thalacker-Mercer A. Peptide YY (PYY) is expressed in human skeletal muscle tissue and expanding human muscle progenitor cells. Front Physiol. 2019 Mar 5;10:188
  20. Blum JE, Gheller BJ, Hwang S, Bender E, Gheller M and *Thalacker-Mercer AE. Consumption of a Blueberry-Enriched Diet by Women for 6 Weeks Alters Determinants of Human Muscle Progenitor Cell Function. J Nutr. 2020 Sep 1;150(9):2412-2418.
  21. Kazemi M, Jarrett BY, Parry SA, Thalacker-Mercer A, Hoeger KM, Spandorfer SD and Lujan ME. Osteosarcopenia in reproductive-aged women with polycystic ovary syndrome: a multicenter case-control study. J Clin Endocrinol Metab. 2020 Sep 1;105(9):dgaa426
  22. Gheller ME, Vermeylen F, Handzlik MK, Gheller BJ, Bender E, Metallo C, Aydemir TB, Smriga M, *Thalacker-Mercer AE. Tolerance to graded dosages of histidine supplementation in healthy human adults. Am J Clin Nutr. 2020 Aug 7:nqaa210. doi: 10.1093/ajcn/nqaa210.
  23. Ntemiri A, Ghosh TS, Gheller ME, Tran TT, Blum JE, Pellanda P, Vlckova K, Neto M, Howell A, Thalacker-Mercer A, and O’Toole PW. (2020) Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human Consumers. Nutrients. 2020 Sep 12;12(9):E2800. doi: 10.3390/nu12092800.
  24. Gheller B, Blum J, Fong E, Malysheva O, Cosgrove B, and *Thalacker-Mercer A. A defined N6-methyladenosine (m6A) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions Cell Death Discov. 2020 Sep 29;6:95.
  25. Gheller BJ, Blum JE, Lim EW, Handzlik MK, Fong EH, Ko A, Khanna S, Gheller ME, Bender EL, Alexander, MS, Stover PJ, Field MS, Cosgrove BD, Metallo CM, and *Thalacker-Mercer AE. Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function. Mol Metab. 2020 Oct 23:101106.
  26. Nichenko AS, Sorensen JR, Southern WM, Qualls AE, Schifino AG, McFaline-Figueroa J, Blum JE, Tehrani KF, Yin H, Mortensen LJ, Thalacker-Mercer AE, Greising SM, Call JA. Lifelong Ulk1-mediated autophagy deficiency in muscle induces mitochondrial dysfunction and contractile weakness. Int J Mol Sci. 2021 Feb 16;22(4):1937
  27. Chen H, Blum JE, Thalacker-Mercer A, Gu Z. Impact of the whole genome duplication event on PYK activity and effects of a PYK1 mutation on metabolism in S. Cerevisia. Front Mol Biosci. 2021 Mar 16;8:656461
  28. JL Fiddler; Y Xiu; JE Blum; SG Lamarre; WN Phinney; SP Stabler; ME Brosnan; JT Brosnan; AE Thalacker-Mercer; MS Field. Reduced Shmt2 expression impairs mitochondrial folate accumulation and respiration, and leads to uracil accumulation in mouse mitochondrial DNA. J Nutr. 2021 Oct 1;151(10):2882-289
  29. Blum JE, Gheller BJ, Benvie A, Field M, Vacanti N, Berry D, *Thalacker-Mercer AE. Pyruvate Kinase M2 supports proliferation of cultured muscle progenitor cells but is dispensable for regeneration after injury. J Nutr. 2021 Nov 2;151(11):3313-3328
  30. Jun S, Cowan AE, Dwyer JT, Campbell WW, Thalacker-Mercer AE, Gahche JJ, and Bailey RL. Higher dietary protein intake is associated with higher appendicular lean mass and handgrip strength among middle-aged U.S. adults. J Nutr. 2021 Dec 3;151(12):3755-3763
  31. Kumar A, Cordes T, Thalacker-Mercer AE, Pajor AM; Murphy A, Metallo CM. NaCT (SLC13A5) facilitates citrate import and metabolism under nutrient-limited conditions. Cell Reports. 2021 Sep 14;36(11):109701
  32. Lakshman Kumar P, Wilson A, Rocco A, Cho MH, Wan E, Hobbs BD, Washko GR, Ortega VE, Christenson S, Li X, Wells J.M., Bhatt SP, Demeo D, Lutz S, Wouters EFM, Rossiter H, Casaburi R, Rennard SI, Lomas DA, Labaki WW, Han MK, Agusti A, Tal-Singer R, Bowler RP, Hersh CP, Tiwari H, Dransfield M, Thalacker-Mercer A, Meyers DA, Silverman EK and McDonald MN. Genetic variation in genes regulating skeletal muscle regeneration and tissue remodeling associated with weight loss in COPD. J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1803-1817.
  33. Guo X, Xu W, Zhang W, Thalacker-Mercer AE, Zheng H, Gu Z. High-frequency and functional mitochondrial DNA mutations at the single-cell level. Proc Natl Acad Sci U.S.A. 2023 Jan 3;120(1).
  34. 34.  Fiddler J, Blum JE, Castillo LF, Thalacker-Mercer AE, Field MS. Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity. Genes Nutr. 2023 Mar 24;18(1):5.

Chapters, Reviews, and Proceedings Articles (*corresponding author)

  1. Thalacker-Mercer AE, and Campbell WW.Dietary protein intake affects albumin fractional synthesis rate equally in younger and older adults.  Nutr Rev. 2008 Feb;66(2):91-5
  2. Guoyao Wu, Jessica Fanzo, Dennis D. Miller, Prabhu Pingali, Mark Post, Jean L. Steiner, and Anna E. Thalacker-Mercer. Production and supply of high-quality food protein for human consumption: sustainability, challenge and innovations. NYAS Annals Meeting Reports. Ann N Y Acad Sci. 2014 Aug;1321(1):1-19
  3. *Thalacker-Mercer AE and Drummond MJ. Protein metabolism in inactive older adults. New York Academy of Sciences. Ann N Y Acad Sci. 2014 Aug 12
  4. Riddle E, Stipanuk M, and *Thalacker-Mercer A. Amino Acids in Healthy Aging Skeletal Muscle. Front Biosci (Elite Ed). 2016 Jan 1;8:326-50.
  5. Gheller BJ, Riddle ES, Lem MR, *Thalacker-Mercer A. Understanding age-related changes in skeletal muscle metabolism: differences between females and males. Annu Rev Nutr. 2016 Jul 17;36:129-56.
  6. Kazemi M, Thalacker-Mercer AE, Lujan ME (2020) Response Letter to the Editor from Smith et al.: Osteosarcopenia in Reproductive-Aged Women with Polycystic Ovary Syndrome: A Multicenter Case-Control Study. J Clin Endocrinol Metab. 2020 Sep 18:dgaa670.
  7. *Thalacker-Mercer A and Gheller ME. Benefits and adverse effects of histidine supplementation. J Nutr. 2020 Oct 1;150(Suppl 1):2588S-2592S.
  8. Blum J, Epstein R, Watts S, *Thalacker-Mercer A. The role of metabolism and nutrient availability in skeletal muscle regeneration: A review. Invited contribution. Research Topic: Nutrition in the Regulation of Muscle Development and Repair. In Press: Front. Physiol., 16 July 2021
  9. *Thalacker-Mercer AE, Field MS. Editorial overview: Food Biotechnology. Curr Opin Biotechnol. 2021 July 8:S0958-1669(21)00104-X
  10. *Thalacker-Mercer A and Blum J. Discovery and application of dietary compounds to optimize human health, a focus on skeletal muscle regeneration. Invited review. Current Opinion in Biotechnology. 2021 May 7;70:131-135
  11. Graham Z, Lavin K, O’Bryan S, Thalacker-Mercer A, Buford T, Ford K, Broderick T, and Bamman M. Mechanisms of exercise as a preventative measure to muscle wasting. Invited Review. AJP Cell. 2021 Jul 1;321(1):C40-C57
  12. Mihaylova MM, Chaix A, Delibegovic M, RamseyJ, Bass J, Melkani G, Singh R, Chen Z, Ja W, Shirasu-Hiza H, LatimerMN, Mattison J, Thalacker-Mercer AE, Dixit VD, Panda S, Lamming DW. When a calorie is not just a calorie: diet quality and timing as mediators of healthy eating and healthy eating. Cell Metabolism. In Press                               

Web-based Peer-Reviewed Publications (*corresponding author)

  1. Gheller, B.J., Blum, J., Soueid-Baumgarten, S., Bender, E., Cosgrove, B.D., *Thalacker-Mercer, A. Isolate, culture, characterize, and differentiate human muscle progenitor cells from the skeletal muscle biopsy procedure. J Vis Exp. 2019(150)
  2. *Thalacker-Mercer AE. Counterbalancing Functional Deficits from Acute Illness Hospitalization. The Deep South CME Network, UAB Geriatric Education Center, UAB Division of CME. www.alabamacme.uab.edu/geriatrics.aspx. May 2012.
  3. Herrington HL, Lawrence JC, Ponder A, Thalacker-Mercer AE, Willis AS, McLinn J.  Weight Management in Older Adults. The Deep South CME Network, UAB Geriatric Education Center, UAB Division of CME. www.alabamacme.uab.edu/geriatrics.aspx. November 2012.