Extracellular space remodeling during neurodegeneration

The implications of the extracellular space on the etiology and progression of neurodegenerative diseases remain largely underexplored. The extracellular space components such as heparan sulfate control the diffusion of misfolded aggregates in the interstitial fluid and, therefore, may impact the progression of neurodegenerative diseases. Our laboratory aims to define the interplay between the extracellular matrix organization, the interstitial fluid diffusion and the progression of prion and α-syn pathologies.